李宜川;刘国玲;孟凡良;
LI Yichuan1,LIU Guoling1,MENG Fanliang2(1.Department of Biochemistry,Shangqiu Medical College,Shangqiu,476000,Henan,China;2. Endocrine Department,Shangqiu Hospital of Chinese Traditional Medicine,Shangqiu 476000,Henan,China)

• 1:商丘医学高等专科学校生物化学教研室
• 2:商丘市中医院内分泌科

摘要(Abstract)：

目的:研究血清超敏C反应蛋白(hs-CRP)和低密度脂蛋白胆固醇(LDL-C)水平的变化对2型糖尿病并发动脉粥样硬化的危险性。方法:收集84例2型糖尿病患者和39例体检正常者的血清,采用乳胶增强免疫比浊法测定血清hs-CRP,一步法测定LDL-C。结果:在正常对照组hs-CRP为(1.23±0.73)mg/L,LDL-C正常组的hs-CRP为(4.57±1.74)mg/L,LDL-C增高组的hs-CRP为(8.53±3.32)mg/L,LDL-C正常组和LDL-C增高组的hs-CRP明显高于正常对照组(P<0.05,P<0.01);LDL-C正常组和LDL-C增高组的hs-CRP水平差异也有非常显著意义(P<0.01);同时hs-CRP水平与LDL-C水平呈正相关(r=0.86,P<0.01)。结论:作为炎症因子,hs-CRP和LDL-C一样参与2型糖尿病并发动脉粥样硬化过程,并可能对其发生、发展有重要预测作用。
Objective:To study the adverse influence of serum levels of high-sensitive C reactive protein (hs-CRP) and low-density lipoprotein (LDL-C ) in patients of type Ⅱ diabetes complicated by artherosclerosis. Method: Serum samples were collected from 84 type Ⅱ diabetes patients (patient group) and 39 normal people (normal control group,group C). Serum level of hs-CRP was detected with latex enhanced immunoturbidimetric assay and LDL-C detected with One-step method. The patient group was further divided into normal LDL-C group (group N) and high LDL-C group (group H) according to their serum LDL-C level. Results: Serum levels of hs-CRP were (1.23±0.73)mg/L ,(4.57±1.74)mg/L ,and (8.53±3.32)mg/L in groups C,N,and H respectively. The hs-CRP levels of group N and H were significantly higher than that of group C (P<0.05,P<0.01,respectively);There was a significant difference between the hs-CRP levels of groups N and H (P<0.01). The hs-CRP level showed a positive correlation with LDL-C level (r=0.86,P<0.01). Conclusion: As an inflammatory factor,hs-CRP participates the artherosclerosis process in diabetes as well as LDL-C,and it could reflect the happening and development of artherosclerosis.

关键词(KeyWords)： 糖尿病,非胰岛素依赖型;C反应蛋白;动脉硬化;脂蛋白类,LDL
diabetes mellitus,non-insulin-dependent;C-reactive protein;artherosclerosis;lipoprotein,LDL

Abstract:

Keywords:

基金项目(Foundation):

作者(Authors): 李宜川;刘国玲;孟凡良;
LI Yichuan1,LIU Guoling1,MENG Fanliang2(1.Department of Biochemistry,Shangqiu Medical College,Shangqiu,476000,Henan,China;2. Endocrine Department,Shangqiu Hospital of Chinese Traditional Medicine,Shangqiu 476000,Henan,China)

DOI: 10.19367/j.cnki.1000-2707.2009.05.015

参考文献(References)：

• [1]叶任高.内科学[M].5版.北京:人民卫生出版社,2002:805-806.
• [2]Report of A WHO Consultation Definition.Diagnosis andclassification of diabetes mellitusandits complication[J].WHO/NCK/NCS,1999:31-33.
• [3]李健斋.血脂分析临床应用若干基本问题[J].国外医学临床生物化学与检验学分册,2002(6):315-317.
• [4]赵学礼,王芳.血清L-血清素、一氧化氮及低密度脂蛋白胆固醇在2型糖尿病大血管病变中的作用[J].临床荟萃,2008(7):489-490.
• [5]Tonari Y,Chida M,koyama T,et al.Estblishment of a reference interval for highly sensitive CRP by exclusinon of individuals with abnormal values in related laborattpry tests[J].Rinsho Byori,2001(2):178-182.
• [6]Ridker PM,Henneken CH,Bueing JE,et al.Creaction protein and other markers of inflammation in the prediction of cardiovascular disease in women[J].N Engl J Med,2000(12):836-843.
• [7]Danesh J,Wheeler JG,Hirschfield GM,et a1.Creactive protein and other circulating markers of inflammation in the prediction of coronary heart disease[J].N Engl J Med,2004(350):1387-1397.
• [8]Abdetmounaleb I,Danchin N,Ilardo C,et a1.C-reacive-protein and coronary artery disease:additional evidence of the implication infl ammantory process in acute coronary syndromes[J].Am Heart J,1999(137):346-351.
• [9]孙艳红,高玲,王东.糖尿病血浆超敏C反应蛋白及胆固醇变化的研究[J].实用医学杂志,2003(1):48.

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