黄耀德,Malcolm B. Carpenter
Huang Yaode,et al Department of Anatomy

• 1:贵阳医学院解剖学教研室
• 2:美国USUHS大学F.Edward H'ebert医学院解剖系 M. D.

摘要(Abstract)：

ABC法研究猴、猫前庭神经核簇(VN)内含P物质(SP)神经元胞体和终末的分布。小型SP免疫反应阳性神经元主要位于前庭神经内侧核(MVN)和前庭神经下核(IVN)的尾侧半。并散在于前庭神经节(VG)。前庭神经外侧核(LVN)内,几乎所有SP免疫反应阴性的大型神经元胞体和近端树突均为阳性终末环绕。提示SP参与前庭脊髓投射的调节。LVN不同部分的SP阳性终末有不同来源。嘴腹侧部者来自VG,尾背侧部者可能来自同侧MVN和1VN。前庭神经上核(SVN)背外侧部、MVN近头端腹外侧部等处的一些中型阴性神经元亦被阳性终末环绕。提示来自初级前庭纤维的SP参与前庭眼肌反射的调节。
The distributions of SP-immunoreactive(SPir)cell bodies and terminals (fine puncta) were studied in the vestibular nuclei (VN) of the squirrel monkey and cat using antiserum to SP and ABC procedure. All the SPir neurons in VN were small. They were mainly found in caudal parts of the medial vestibular nucleus (MVN) and inferior vestibular nucleus (1VN). Small SPir neurons also scattered in the vestibular ganglia (VG). SPir terminals surrounded somata and proximal dendrites of almost all the unstained giant cells of the lateral vestibular nucleus (LVN) , which suggested thas SP might play a role in modulation of the vestibulospinal projection, and that the SPir fibers to the ventral LVN might derive from VG and the fibers to the dorsal LVN, from ipsilateral MVN and IVN. SPir terminals also outlined a few unstained medium-sized neurons in peripharal part of superior vestibular nucleus(SVN), ventrolateral part of rostral MVN, rostrodorsal part of IVN and dorsal "y" in monkey, thereby suggesting the modulation of the vestibulo-ocular reflex by primary vestibular SPir fibers.

关键词(KeyWords)： 前庭神经核;P物质;免疫组织化学;松鼠猴;猫
vestibular nuclei; substance P; immunohistochemistry; squirrel monkey; cat

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 黄耀德,Malcolm B. Carpenter
Huang Yaode,et al Department of Anatomy

DOI: 10.19367/j.cnki.1000-2707.1991.04.001

参考文献(References)：

• 1． Henry JL. Effects of substance P on functionally identified units in cat spinal cord. Brain Res 1976;114: 439-451．
• 2． Lembeck F, et al. Analgesic effect of antagonists of substance P. Biochem Biophys Res Commun 1981; 103: 1318-1321．
• 3． Somogyi P, et al. Synaptic connections of substance P-immunoreactive nerve terminals in the substantia nigra of the rat. Cell Tissue Res 1982; 223: 469-486．
• 4． Sperk G, et al. In vivo synthesis of substance P in the corpus striatum of the rat and its transport to the substantia nigra. Brain Res 1982; 238: 127-135．
• 5． Nomura I, et al. Neuropeptides and gamma-aminobutyric acid in the vestibular nuclei of the rat: an immunohistochemical analysis. I. Distribution. Brain Res 1984; 311: 109-118．
• 6． 黄耀德,等.谷氨酸和胆碱乙酰化酶 免疫反应阳性神经元在猴、猫前庭神经核簇的分布与比较.贵阳医学院学报1991;16:152-157．
• 7． Hokfelt T, et al. Peptidergic neurones. Nature 1980; 284: 515-521．
• 8． Ylikoski J, et al. Substance P-like immunoreactivity in the inner ear structure of the rabbit. In: Skrabanek P, et al(eds). Substance P. Dublin: Boole Press 1983; 206-207．
• 9． Brodal A. Anatomy of the vestibular nuclei and their connections. In: Kornhuber HH(ed). Handbook of sensory physiology, vestibular system, morphology. Vol Ⅵ/1． New York: Springer-Verlag, 1974: 240-352．
• 10． Brodal A. The vestibular nuclei in the macaque monkey. J Comp Neurol 1984; 227: 252-266．
• 11． Rubertone JA, et al. The intrinsic organization of the vestibular complex: evidence for internuclear connectivity. Brain Res 1983; 263: 137-141．
• 12． Cuello AC, et al. The distribution of substance P immunoreaetive fibers in the rat central nervous system. J Comp Neurol 1978; 178: 129-156．
• 13． Carpenter MB, et al. Connections. and oculomotor projections of the superior vestibular nucleus and cell group "y". Brain Res 1985; 336: 165-187．
• 14． Mitsacos A, et al. The superior vestibular nucleus: an intracellular HRP study in the cat. Ⅰ. vestibulo-ocular neurons. J Comp Neurol 1983; 215: 78-91．
• 15． Carlcton SC, et al. Afferent and efferent connections of the medial, inferior and lateral vestibular nuclei in the cat and monkey. Brain Res 1983; 287: 29-51．
• 16． Konishi S, et al. Excitatory action of hypothalamic substance P on spinal motoneurones of newborn rats. Nature 1974; 252: 734-735．

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