訾聃,杨英捷,陈景端
ZI Dan,YANG Ying-jie,CHEN Jing-duan(Department of Obstetrics and Gynecology

• 1:贵阳医学院附院妇产科
• 2:贵阳医学院附院妇产科
• 3:贵阳医学院附院妇产科 贵州贵阳550004
• 4:贵州贵阳550004

摘要(Abstract)：

目的:研究肝细胞生长因子(HGF)受体C-m et蛋白与细胞增殖核抗原K i-67在子宫内膜癌中的表达及二者的关系,探讨其在子宫内膜癌发病中的意义。方法:应用免疫组织化学Envision法对41例子宫内膜癌、17例子宫内膜非典型增生及35例子宫增生期内膜组织中C-m et蛋白和K i-67表达进行检测,并对子宫内膜癌组的分化程度、手术-病理分期、肌层浸润、淋巴结转移的临床情况进行分析。结果:C-m et及K i-67在子宫内膜非典型增生的表达高于正常增生期内膜,在子宫内膜癌中的表达又高于子宫内膜非典型增生,有显著性差异(P<0.05);在子宫内膜癌中C-m et与K i-67密切正相关(r<1,P<0.01),且均与子宫内膜癌分化程度、手术-病理分期相关(P<0.05)。结论:C-m et蛋白和K i-67在子宫内膜癌中的表达明显增高,二者呈正相关性,可能共同促进肿瘤细胞的增殖、分化,对子宫内膜癌的发生、发展具有重要作用,并可能成为判断子宫内膜癌预后的重要指标。
Objective: To study the distribution and expression of hepatocyte growth factor receptor(C-met) protein and cell generation nuclear antigen(Ki-67) in endometrial carcinoma and their relationship.Methods: Expression of C-met and Ki-67 were detected in tissue of 41 cases of endometrial carcinoma,17 cases of atypical hyperplasia,and 35 cases of normal endometrium by immunohistochemical envision assay.The relativity of endometrial carcinoma with clinico-pathologic feature and prognosis was analyzed.Results: The expression of C-met and Ki-67 in atypical hyperplsia was higher than that in normal endometrium,and it was even higher in endometrial carcinoma than that in atypical hyperplsia(P<0.05).In endometrial carcinoma,the expression of C-met was significantly correlated with Ki-67(r<1,P<0.01).The expression of C-met and Ki-67 were related to endometrial carcinoma differentiation degree,and operation-pathological stages(P<0.05).Conclusions: C-met and Ki-67 express strongly in endometrial carcinoma.There is a positive correlation between the expression of C-met and Ki-67.They might promote cell proliferation,motility and contribute to the progression of endometrial carcinoma.The expression and collocation of C-met and Ki-67 can be used as two useful prognostic factors of endometrial carcinoma.

关键词(KeyWords)： 癌,子宫内膜样;原癌基因蛋白质C-met;Ki-67抗原
carcinoma,endometrioid;proto-oncogene protein C-met;Ki-67 antigen

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 訾聃,杨英捷,陈景端
ZI Dan,YANG Ying-jie,CHEN Jing-duan(Department of Obstetrics and Gynecology

DOI: 10.19367/j.cnki.1000-2707.2005.06.015

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