潘晔,韩佳,杜鸿瑶,鲁静
PAN Ye,HAN Jia,DU Hongyao,LU Jing

• 1:唐山市中医医院心血管三科

摘要(Abstract)：

目的 探讨化痰祛瘀法对冠心病稳定型心绞痛患者外周血线粒体钙转运与动脉粥样硬化指数(AI)的影响。方法 选取冠心病稳定型心绞痛患者100例，按随机数表法均分为对照组和观察组，对照组采用西医常规治疗，治疗组在西医常规治疗基础上+化痰祛瘀方治疗，连续治疗8周；分别于治疗前及治疗结束时，采用西雅图心绞痛量表(SAQ评分)评估两组患者的心绞痛程度，双试剂酶法检测两组患者甘油三酯(TG)、总胆固醇(TC)及低密度脂蛋白胆固醇水平(LDL-C),全自动血流变检测仪测定血液流变学指标，电化学发光法测定血清线粒体钙离子单向转运蛋白(MCU)水平，颈动脉超声检测两组患者AI,并比较两组患者的临床疗效。结果 治疗结束后，两组患者躯体受限程度、心绞痛稳定状态、心绞痛发作情况、治疗满意程度及疾病认识程度等SAQ评分均较治疗前上升，且观察组均高于对照组(P<0.05);两组患者TG、TC、LDL-C治疗后水平均较治疗前下降，且观察组低于对照组(P<0.05);两组全血高切黏度、全血低切黏度、血浆黏度及纤维蛋白原治疗后水平均较治疗前下降，且观察组均低于对照组(P<0.05);两组患者治疗后MCU水平较治疗前上升、AI较治疗前下降，且治疗后观察组MCU水平高于对照组、AI水平低于对照组(P<0.05);治疗后，观察组临床总疗效高于对照组，差异有统计学意义(P<0.05)。结论 化痰祛瘀法对冠心病稳定型心绞痛患者有较好疗效，其机制可能与改善外周血线粒体钙转运功能及AI有关。
Objective To investigate the effect of the strategy of eliminating phlegm and removing stasis on mitochondrial calcium transport and atherosclerosis index(AI) in peripheral blood of patients with stable angina pectoris of coronary heart disease(CHD). Methods A total of 100 CHD patients with stable angina pectoris were selected and randomly divided into control and observation groups. Control group was treated with conventional western medicine, and observation group was treated with Huatan-Quyu decoction on the basis of conventional western medicine. The treatment course lasted 8 weeks. Before and at the end of the treatment, the degree of angina pectoris was evaluated by Seattle angina questionnaire(SAQ), and double reagent enzymatic method was used to determine the levels of triglyceride(TG), total cholesterol(TC), low-density lipoprotein cholesterol(LDL-C). Blood Rheology Analyzer was used to measure hemorheological indexes. Electrochemiluminescence method was used to measure serum mitochondrial calcium uniporter(MCU) level. Carotid artery ultrasound was used to detect AI in two groups of patients, and the clinical efficacy of the patients was compared between two groups. Results After the treatment, SAQ scores of two groups of patients were higher than before treatment, including the degree of physical limitation, stable state of angina pectoris, episode of angina pectoris, treatment satisfaction and disease awareness. SAQ scores in observation group were higher than those in control group(P<0.05). After treatment, the levels of TG, TC, and LDL-C in two groups were lower than before treatment, and they were lower in observation group than those in control group(P<0.05). After treatment, the levels of high-shear blood viscosity, low-shear blood viscosity, plasma viscosity and fibrinogen in two groups were lower than before treatment, and they were lower in observation group than those in control group(P<0.05). After treatment, MCU levels were increased and AI levels were decreased in both groups of patients when compared to before treatment. After treatment, MCU level in observation group was higher than that in control group, while AI level was lower than that in control group(P<0.05). After treatment, the total clinical efficacy of observation group was higher than that of control group(P<0.05). Conclusion The strategy of eliminating phlegm and removing blood stasis has a good effect on patients with stable angina pectoris of coronary heart disease, and its mechanism may be related to improving mitochondrial calcium transport function and AI in peripheral blood.

关键词(KeyWords)： 冠心病稳定型心绞痛;化痰祛瘀法;疗效;外周血线粒体钙转运;动脉粥样硬化指数
stable angina pectoris of coronary heart disease;eliminating phlegm and removing stasis;therapeutic effect;mitochondrial calcium transport in peripheral blood;atherosclerosis index

Abstract:

Keywords:

基金项目(Foundation): 河北省中医药类科研计划课题（2022548）

作者(Author): 潘晔,韩佳,杜鸿瑶,鲁静
PAN Ye,HAN Jia,DU Hongyao,LU Jing

DOI: 10.19367/j.cnki.2096-8388.2024.06.017

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