贵州医科大学学报

2009, v.34;No.141(06) 649-651+654

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菊黄上清含片抗流感病毒的研究
An Experimental Study on Antiviral Activity of Juhuangshangqing Buccal Tablet

骆勇;李翠兵;兰燕宇;左丽;
LUO Yong1,LI Cuibing2,LAN Yanyu2,ZUO Li3(1.Guizhou Provincial Institute for Drug Control,Guiyang 550004,Guizhou,China;2.School of Pharmacology,Guiyang Medical College,Guiyang 550004,Guizhou,China;3.Department of Immunology,Guiyang Medical College,Guiyang 550004,Guizhou,China)

摘要(Abstract):

目的:研究菊黄上清含片在小鼠体内的抗流感病毒作用。方法:以流感病毒鼠肺适应株FM1滴鼻感染小鼠,用高、中、低浓度菊黄上清含片药液灌胃小鼠,观察小鼠的生存时间、死亡率、肺指数和肺组织病变程度。结果:菊黄上清含片对流感病毒FM1致小鼠肺病变有明显抑制作用,对流感病毒FM1感染小鼠具有显著的保护作用,明显抑制小鼠体内流感病毒FM1的增殖。结论:菊黄上清含具有明显的抗流感病毒作用。
Objective:To study the effects of Juhuangshangqing buccal tablet against influenza virus.Methods:Mouse influenza infection model was established by nose dripping with stock FM4 of influenza virus which was adapted to mouse lung specially.Juhuangshangqing buccal tablets were given to the experimental mice with different amounts,and their survival time,mortality,lung index,and pathological change degree of lung tissue were observed.Results:Juhuangshangqing buccal showed obvious inhibitory effect to pulmonary pathological changes,and reduced virus multiplication and mortality of influenza virus infected mice.Conclusions:Juhuangshangqing buccal tablets have obvious effects against influenza virus.

关键词(KeyWords): 病毒;感冒;菊黄上清含片;死亡率;肺炎,病毒性;病理学;小鼠
viruses;common cold;Juhuangshangqing buccal;mortality;pneumonia,viral;pathology;mice

Abstract:

Keywords:

基金项目(Foundation): 贵州省中药现代化科技产业开发专项项目[黔科合农字(2005)5039号]

作者(Author): 骆勇;李翠兵;兰燕宇;左丽;
LUO Yong1,LI Cuibing2,LAN Yanyu2,ZUO Li3(1.Guizhou Provincial Institute for Drug Control,Guiyang 550004,Guizhou,China;2.School of Pharmacology,Guiyang Medical College,Guiyang 550004,Guizhou,China;3.Department of Immunology,Guiyang Medical College,Guiyang 550004,Guizhou,China)

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DOI: 10.19367/j.cnki.1000-2707.2009.06.017

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