贵州医科大学学报

2019, v.44;No.221(02) 147-152

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气相色谱-质谱联用分析飞龙掌血根皮油的化学成分
GC-MS Analysis of Chemical Constituents of Root Bark Oil of Toddalia asiatica

周威;罗才荣;刘刚;董伟强;张晓燕;沈祥春;
ZHOU Wei;LUO Cairong;LIU Gang;DONG Weiqiang;ZHANG Xiaoyan;SHEN Xiangchun;School of Pharmacy,Guizhou Medical University;School of Basic Medical Sciences,Guizhou Medical University;R&D center,Zhejiang Keqiang Pharmaceutical Technology Co.,Ltd.;

摘要(Abstract):

目的:气相色谱-质谱联用(GC-MS)分析飞龙掌血根皮油的化学成分。方法:采用95%乙醇冷浸提取得到飞龙掌血根皮提取物、进一步经石油醚萃取、最终得到飞龙掌血根皮部位的脂溶性油,运用GC-MS技术对飞龙掌血根皮油化学成分进行定性定量分析。结果:从飞龙掌血根皮油中鉴定出了41种化合物,其中烯烃类化合物占40. 67%、醇类成分占22. 21%、香豆素类成分占16. 11%、酮类成分占13. 91%、酰胺类成分占3. 93%、酯类成分占3. 17%,含量最多的是cubebol类异构体。结论:飞龙掌血根皮油中化学成分基本上都属于双环脂环烃类。
Objective: To analyze chemical constituents of the root bark oil of Toddalia asiatica by applying GC-MS technique. Methods: The root bark extract of Toddalia asiatica was extracted by95% ethanol merceration,liposoluble oil of root bark part of Toddalia asiatica was finally obtained by further petroleum ether extraction of the previously-prepared root bark extract. The qualitative and quantitative analysis of the root bark oil of Toddalia asiatica was carried out by means of GC-MS technique. Results: There were 41 compounds extracted from root bark oil of Toddalia asiatica,in which alkenes accounted for 40. 67%,alcohols accounted for 22. 21%,coumarins accounted for 16. 11%,ketones accounted for 13. 91%,amides accounted for 3. 93%,and esters accounted for 3. 17%. The single compound with the highest content in root bark oil of Toddalia asiatica is the cubebol isomer.Conclusion: The chemical constituents of root bark oil of Toddalia asiatica were mainly bicyclic aliphatic hydrocarbons.

关键词(KeyWords): 飞龙掌血;根皮油;气相色谱-质谱法;药物成分分析
Toddalia asiatica;root bark oil;gas chromatography-mass spectrometry;medicine component analysis

Abstract:

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基金项目(Foundation): 国家自然科学基金(81360681);; 贵州省特色天然药物资源活性研究科技创新团队[(2015)4025];; 贵州省高等学校科技创新人才团队[(2014)31];; 贵州省高层次创新型人才“百层次”人才项目[(2015)4029];; 贵州省高层次创新型人才“千层次”人才项目(2016-2018)

作者(Author): 周威;罗才荣;刘刚;董伟强;张晓燕;沈祥春;
ZHOU Wei;LUO Cairong;LIU Gang;DONG Weiqiang;ZHANG Xiaoyan;SHEN Xiangchun;School of Pharmacy,Guizhou Medical University;School of Basic Medical Sciences,Guizhou Medical University;R&D center,Zhejiang Keqiang Pharmaceutical Technology Co.,Ltd.;

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DOI: 10.19367/j.cnki.1000-2707.2019.02.005

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