贵州医科大学学报

2020, v.45;No.232(01) 91-96

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口腔鳞状细胞癌组织CIRP和TLR4蛋白表达与患者临床病理特征及预后的关系
Relationship between Expression of CIRP and TLR4 in Oral Squamous Cell Carcinoma and Clinic-pathological Features and Prognosis

张琳梅;高岭;李少明;陈诚;
ZHANG Linmei;GAO Lin;LI Shaoming;CHEN Cheng;Stomatology College of Xi'an Medical University;Department of Maxillofacial Surgey, the Affiliated Hospital of Qingdao University;Department of General Dentistry, Xi'an Jiaotong University Stomatological Hospital;

摘要(Abstract):

目的:探讨口腔鳞状细胞癌(OSCC)组织中冷诱导RNA结合蛋白(CIRP)和Toll样受体4(TLR4)的表达与患者临床病理特征及预后的关系。方法:选取确诊的40例OSCC患者癌组织标本作为研究组、瘤周正常组织作为对照组;收集患者的临床病理特征,采用免疫组织化学染色检测CIRP和TLR4蛋白的表达;电话随访患者或其家属,收集死亡患者的生存时间,采用Kaplan-Meier法分析死亡患者CIRP和TLR4表达对预后的影响。结果:研究组CIRP和TLR4蛋白阳性检出率均明显高于对照组,差异均有高度统计学意义(P<0.01);癌组织CIRP蛋白高、低表达组的患者TNM分期、临床分期、组织病理学分期及淋巴结转移的差异均有统计学意义(P<0.05),癌组织TLR4高、低表达组患者的性别、TMN分期、临床分期、组织病理学分级以及淋巴结转移的差异均有统计学意义(P<0.05);随访结果显示,癌组织CIRP高表达患者术后的生存率明显低于低表达患者(χ~2=6.651,P=0.009),癌组织TLR4高表达患者术后的生存率明显低于TLR4低表达患者(χ~2=8.473,P=0.004)。结论:CIRP与TLR4在OSCC癌组织中呈高表达,并与患者TNM分期、临床分期、组织病理学分期、淋巴结转移以及较差的生存率有关联。
Objective: To investigate the expression of cold induced RNA combined protein(CIRP) and Toll-like receptor 4(TLR4) of oral squamous cell carcinoma(OSCC) and its relationship with clinic-pathological features and prognosis. Methods: Selecting 40 cases of OSCC patients sample as experiment group, peritumoral-normal tissue as control group; collecting clinic-pathological features of patients, adopting Immunohistochemical staining to evaluate the expression of CIRP and TLR4; phone call follow-up on patients or family to collect survival time of deceased patients. Adopting Kaplan-Meier assay to analyze effect of CIRP and TLR4 of deceased patients on prognosis. Results: The positive detection rate of CIRP and TLR 4 in the experiment group was higher than that of the control group, differences were highly statistically significant(P<0.01); the differences of TNM staging, clinical staging, histopathological staging and lymph node metastasis of of CIRP protein high and low expression groups were statistically significant(P<0.05); the differences of gender, TNM staging, clinical staging, histopathological staging and lymph node metastasis of of TLR4 high and low expression groups were statistically significant(P<0.05). The overall survival rate of patients with high CIRP expression was lower than that of patients with low expression(χ~2=6.651,P=0.009), overall survival rate of patients with high TLR4 expression was lower than that of patients with low expression(χ~2=8.473,P=0.004). Conclusion: CIRP and TLR4 showed high expression in OSCC patients, which was correlated with TNM staging, clinical staging, histopathological staging and lymph node metastasis as well as poor survival rate.

关键词(KeyWords): Toll样受体4;口腔鳞状细胞癌;免疫组织化学;病理学,临床;冷诱导RNA结合蛋白;肿瘤预后
toll-like receptor 4;oral squamous cell carcinoma;immunohistochemistry;pathology,clinical;cold inducible RNA binding protein;prognosis

Abstract:

Keywords:

基金项目(Foundation): 陕西省教委基金(19JK0764)

作者(Author): 张琳梅;高岭;李少明;陈诚;
ZHANG Linmei;GAO Lin;LI Shaoming;CHEN Cheng;Stomatology College of Xi'an Medical University;Department of Maxillofacial Surgey, the Affiliated Hospital of Qingdao University;Department of General Dentistry, Xi'an Jiaotong University Stomatological Hospital;

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DOI: 10.19367/j.cnki.1000-2707.2020.01.018

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