张春蕾,张丹丹
ZHANG Chunlei,ZHANG Dandan (Jiamusi College

• 1:黑龙江中医药大学佳木斯学院

摘要(Abstract)：

目的:研究七味都气丸对D-半乳糖致衰小鼠记忆力、抗氧化能力的影响。方法:将小鼠随机分为6组,每组10只,正常对照组(Ⅰ)、模型对照组(Ⅱ)、维生素E组(Ⅲ)、七味都气丸低剂量组(Ⅳ)、七味都气丸中剂量组(Ⅴ)、七味都气丸高剂量组(Ⅵ),除正常对照组外其余各组用D-半乳糖制造衰老模型,再分别给予维生素E和不同浓度的七味都气丸,6周后测定各组小鼠学习记忆行为,测定血清中超氧化物歧化酶(SOD)活力及脑组织中乙酰胆碱酯酶(AchE)活力。结果:七味都气丸能明显提高衰老模型鼠对电刺激的逃避能力,并可提高血清中的SOD及脑组织AchE活力。结论:七味都气丸可改善D-gal致衰小鼠学习记忆能力,有效清除自由基,使机体各项生理功能得到明显改善,起到抗衰老作用。
Objective:To study the effects of Qiweiduqi pill(QWDQP) on memory and anti-oxidation abilities of aging rats caused by D-gal.Methods:Rats were randomly divided into 6 groups with 10 in each group:normal control group(Ⅰ),model group(Ⅱ),vitamin E group(Ⅲ) and groups of low,moderate,high doses of QWDQP(groups Ⅳ,Ⅴ,and Ⅵ).Ageing models were established using D-glucose with rats in all the groups except groupⅠ,and then were given vitamin E or different doses of QWDQP respectively.Memory ability,serum superoxide dismutase(SOD) and brain acetylcholinesterase(AchE) activities of rats were detected.Results:QFDQP could improve escaping ability of aging rats stimulated by electricity and could also improve activities of serum SOD and brain AchE.Conclusion:QWDQP can improve memory ability of aging rats and is effective in clearing free radicals.So QWDQP makes physiological function better apparently and acts anti-aging function.

关键词(KeyWords)： 七味都气丸;乙酰胆碱酯酶;超氧化物歧化酶;小鼠;学习记忆
Qiweiduqi pill;acetylcholinesterase;superoxide dismutase;mice;learning and memory

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 张春蕾,张丹丹
ZHANG Chunlei,ZHANG Dandan (Jiamusi College

DOI: 10.19367/j.cnki.1000-2707.2011.04.008

参考文献(References)：

• [1]许凯,吕明方.抗衰老药物学[M].中国医药科技出版,1994:56.
• [2]冯时傧.七味都气丸临床应用举偶[J].医学文选,2000(19):107.
• [3]赵鹏,杨玉英.半乳糖制备亚急性衰老动物模型的可行性[J].中国食品卫生杂志,1999(1):52.
• [4]王跃春.Y型电迷宫在小鼠学习记忆功能测试中的合理运用[J].中国行为医学科学,2005(1):69.
• [5]许凯,吕明方.抗衰老药物学[M].中国医药科技出版,1994:56.
• [6]裘维焰.补肾健脾活血法抗衰老作用的实验研究[J].中国老年学杂志,1998(8):294-296.
• [7]刘岳松.抗衰防老话中药(六).五味子[J].中国老年,1998(5):43.
• [8]黄兆胜,刘明平.养寿丹对阿尔茨海默病肾阳虚小鼠脑神经递质的影响[J].中国实验方剂学杂志,2002(1):26.

文章评论(Comment)：