陈妍惠,艾戎
CHEN Yanhui,AI Rong

• 1:贵州医科大学
• 2:贵州医科大学附院儿科

摘要(Abstract)：

目的:探讨影响小儿癫痫持续状态(SE)近期疗效的因素。方法:104例SE住院治疗患儿,按性别、发病年龄、病因、诱因、发作类型、控制时间及治疗方案和相关检查(脑电图、头颅CT及头颅MRI)结果进行分组,采用χ2检验分析不同分组SE患儿出院时的近期治疗效果,分析影响SE患儿近期治疗的因素。结果:各年龄组SE患儿的病因多为癫痫,惊厥性癫痫持续状态(CSE)病因亦为癫痫(68.48%),以全身性CSE为主(91.3%);非惊厥性癫痫持续状态(NCSE)病因多为颅内感染(50%);按性别、发病年龄、病因、诱因、临床发作类型,头颅CT、头颅MRI及脑电图结果分组,各分类依据的SE患儿组间近期疗效比较,差异无统计学意义(P>0.05),按治疗方案分组的SE患儿的近期疗效比较,咪达唑仑组治疗有效率(100%)高于非咪达唑仑组有效率(84.09%),差异有统计学意义(P<0.05)。结论:治疗方案是影响SE近期疗效的因素。
Objective: To investigate influential factors affect child epilepsy status epileptius( SE).Methods: 104 SE children patients were grouped according to gender,age of onset,etiological factors,inducement,clinical seizure types and the relevant factors impacting the short-term effects of status epilepticus in children( EEG,skull CT and skull MRI). χ2was adopted to test short-term efficacy of different groups SE children patients,and then analyzing influential factors. Results: Epilepsy was the main etiology factors for different groups SE children patients,CSE etiology factor was also epilepsy( 68. 48%),featured with full body CSE( 91. 3%); NCSE etiology factor was mainly intracranial infection( 50%); grouped according to gender,age of onset,etiology factors,clinical seizure types,skull CT,skull MRI and EEG,short term efficacy comparison was made,differences showed statistical significance( P < 0. 05); short-term efficacy according to treatment categorization showed that midazolam group TER therapeutic efficiency ratio( 100%) was higher than non-midazolam group( 84h09%),differences were statistical significant( P < 0. 05). Conclusion: The difference of treatment plans is the factor affecting the short-term efficacy of SE.

关键词(KeyWords)： 癫痫持续状态;咪达唑仑;临床特点;近期疗效;影响因素
status epilepticus;midazolam;clinical features;short-term effects;influence factor

Abstract:

Keywords:

基金项目(Foundation): 贵州省省长基金临床应用课题专项研究(No:2012118)

作者(Author): 陈妍惠,艾戎
CHEN Yanhui,AI Rong

DOI: 10.19367/j.cnki.1000-2707.2016.04.032

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