贵州医科大学学报

2012, v.37;No.155(02) 156-158

[打印本页] [关闭]
本期目录(Current Issue) | 过刊浏览(Past Issue) | 高级检索(Advanced Search)

乙肝后肝硬化患者血清ghrelin、瘦素与胰岛素抵抗的关系
The Relationship of Insulin Resistance to Serum Ghrelin and Leptin in Patients with HBV-related Hepatocirrhosis

黄惠妍;周力;
HUANG Huiyan,ZHOU Li(Department of Gastroenterology,the Affiliated Hospital of Guiyang Medical College,Guiyang 550004,Guizhou,China)

摘要(Abstract):

目的:探讨乙肝后肝硬化患者ghrelin、瘦素(Leptin)水平变化规律及其与胰岛素抵抗的关系。方法:选择乙肝后肝硬化患者100例,按肝功能Child A、B、C 3级分组,正常对照组36例,测定各组空腹血糖(FPG)、空腹胰岛素(FINS)、ghrelin及Leptin指标,计算胰岛素抵抗指数(IRS)并进行对比分析。结果:乙肝后肝硬化患者FPG、FINS、IRS、Leptin水平高于对照组,ghrelin水平低于对照组,差异有统计学意义(P<0.01);肝硬化患者A级、B级、C级三组之间FINS、IRS、ghrelin、Leptin差异有统计学意义(P<0.01),FINS、IRS、leptin水平随Child分级升高而升高(P<0.05),ghrelin水平随Child分级的升高而降低(P<0.05)。结论:ghrelin和Leptin水平的变化与乙肝后肝硬化患者的胰岛素抵抗密切相关,ghrelin和瘦素水平的测定对肝硬化病情严重程度的评价有重要临床价值。
Objective: To explore the relationship of insulin resistance to serum ghrelin and leptin in patients with HBV-related hepatocirrhosis.Methods: One hundred patients with HBV-related hepatocirrhosis(35 with Child-Pugh A liver function,33 with Child-Pugh B,and 32 with Child-Pugh C) and 36 normal controls were included in the study.Fasting plasma glucose(FPG),fasting insulin(FINS),serum ghrelin and leptin were analyzed.Insulin resistance index(IRS) was calculated.All parameters of each group were compared.Results: FPG,FINS,IRS and leptin levels in patients with HBV-related hepatocirrhosis were higher and ghrelin levels were lower than those of normal controls(P<0.01).Statistical differences were found in FPG,FINS,IRS,ghrelin and leptin levels among Child-Pugh A,B and C groups(P<0.01).With the Child-Pugh classification rising,FINS,IRS and leptin levels increased(P<0.05) and ghrelin levels decreased(P<0.05).Conclusions: Changes of serum ghrelin and leptin are closely correlated with insulin resistance of patients with HBV-related hepatocirrhosis.Measuring Ghrelin and leptin levels may have critical clinical value for the evaluation of the severity of cirrhosis.

关键词(KeyWords): 肝炎,乙型;肝硬化;瘦素;胰岛素;ghrelin
hepatitis B;liver cirrhosis;leptin;insulin;ghrelin

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 黄惠妍;周力;
HUANG Huiyan,ZHOU Li(Department of Gastroenterology,the Affiliated Hospital of Guiyang Medical College,Guiyang 550004,Guizhou,China)

Email:

DOI: 10.19367/j.cnki.1000-2707.2012.02.014

文章评论(Comment):

序号(No.) 时间(Time) 反馈人(User) 邮箱(Email) 标题(Title) 内容(Content)
反馈人(User) 邮箱地址(Email)
反馈标题(Title)
反馈内容(Content)
扩展功能
本文信息
服务与反馈
本文关键词相关文章
本文作者相关文章
中国知网
分享