贵州医科大学学报

2019, v.44;No.224(05) 601-605

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左卡尼汀对维持性血液透析患者肾性贫血的疗效及心脏结构和功能的影响
Effect of Levocarnitine Injection on Renal Anemia and Cardiac Morphological Structure and Function in Patients with Maintenance Hemodialysis

欧阳山丹;林珍;李阿云;
OUYANG Shandan;LIN Zhen;LI Ayun;Department of Pharmacy, Chinese PLA 73~(rd) Group Military Hospital & Chinese PLA 174 Hospital;

摘要(Abstract):

目的:探讨左卡尼汀注射液对维持性血液透析患者肾性贫血的临床疗效及心脏结构和功能的影响。方法:肾性贫血患者180例随机均分为研究组与对照组,对照组采用人重组促红细胞生成素治疗,研究组在对照组治疗基础上联合左卡尼汀治疗,两组持续治疗12周;于治疗前及治疗12周时,检测体质量指数(BMI)、血红蛋白(Hb)、红细胞压积(Hct)、血清白蛋白(ALB),超声心动图检测左心房内径(LAD)、左室射血分数(LVEF)、左心室舒张末期内径(LVEDD)及左心室心肌质量指数(LVMI),治疗12周时评价治疗效果。结果:两组肾性贫血患者治疗12周时BMI、Hb、Hct及ALB均较治疗前显著上升(P<0.05),观察组治疗12周时BMI、Hb、Hct及ALB水平均显著高于同时段对照组(P<0.05);治疗12周时,研究组患者LAD、LVEDD及LVMI低于治疗前、LVEF高于治疗前(P<0.05),且与同时段对照组比较差异有统计学意义(P<0.05);研究组患者治疗总有效率显著高于对照组(P<0.05)。结论:左卡尼汀可有效改善维持性血液透析患者肾性贫血症状、改善心脏结构和功能。
Objective: To investigate the effect of L-carnitine injection on renal anemia and cardiac morphological structure and function in patients with maintenance hemodialysis. Methods: 180 patients with renal anemia were randomly divided into study group and control group with equal number. The control group was treated with recombinant human erythropoietin, and the study group was treated with Levocarnitine in addition to the treatment of the control group, all of which lasted for 12 weeks. Following index were tested before treatment and 12 weeks after treatment: BMI, Hb, Hct, ALB, LAD, LVEF, LVEDD and LVMI; evaluating treatment efficacy after 12 weeks of treatment. Results: BMI, Hb, Hct and ALB of both groups increased significantly after 12 weeks of treatment(P<0.05); BMI, Hb, Hct and ALB levels in the study group were significantly higher than those in the control group after 12 weeks of treatment(P<0.05). Echocardiographic results showed that only LAD, LVEDD and LVMI decreased significantly and LVEF increased significantly in the study group after 12 weeks of treatment(P<0.05), and there were significant differences between the two groups after treatment of the same time(P<0.05). The total effective rate of the study group was significantly higher than that of the control group(P<0.05). Conclusion: L-carnitine can effectively improve the symptoms of renal anemia in maintenance hemodialysis patients and restore the normal cardiac structure.

关键词(KeyWords): 左卡尼汀;维持性血液透析;肾性贫血;疗效;心脏结构;超声心动图
L-carnitine;maintenance hemodialysis;renal anemia;therapeutic effect;cardiac structure;echocardiography

Abstract:

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作者(Author): 欧阳山丹;林珍;李阿云;
OUYANG Shandan;LIN Zhen;LI Ayun;Department of Pharmacy, Chinese PLA 73~(rd) Group Military Hospital & Chinese PLA 174 Hospital;

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DOI: 10.19367/j.cnki.1000-2707.2019.05.021

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