贵州医科大学学报

2015, v.40;No.174(03) 307-309

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重组人生长激素对老年胸外伤患者蛋白质代谢及免疫功能的影响
The Influence of Recombinant Human Growth Hormone on Protein Anabolism and the Immunologic Function in Elderly Thoracic Trauma Patients

何鹏;周青山;
HE Peng;ZHOU Qingshan;Central Hospital of Xiaogan City;People's Hospital of Wuhan University;

摘要(Abstract):

目的:探讨重组人生长激素(rh GH)对老年胸外伤患者蛋白质代谢及免疫功能的影响。方法:98例老年胸外伤患者随机均分为观察组和对照组,对照组给予标准肠内营养治疗,观察组在对照组治疗基础上给予rh GH治疗,观察并比较2组患者治疗前后血清蛋白水平和免疫功能变化。结果:治疗前,两组患者血清白蛋白、血清前白蛋白以及血清转铁蛋白浓度比较差异无统计学意义(P>0.05),治疗后观察组显著高于治疗前(P<0.01),而对照组无明显变化(P>0.05);治疗后观察组显著高于对照组,差异有统计学意义(P<0.01);治疗前,两组患者血清Ig A、Ig G、Ig M、CD3、CD4、CD8及CD4/CD8比较差异无统计学意义(P>0.05),治疗后观察组Ig A、Ig G、Ig M、CD3及CD4/CD8均显著高于治疗前,对照组仅Ig A、Ig G、Ig M显著增高,而CD3、CD4、CD4/CD8显著降低,差异均有统计学意义(P<0.01);治疗后观察组Ig A、Ig G、Ig M、CD3、CD4及CD4/CD8均显著高于对照组,差异均有统计学意义(P<0.01)。结论:rh GH用于老年胸外伤治疗能促进机体蛋白质含量增加,并能够提高CD3、CD4及CD4/CD8水平,改善患者机体免疫功能。
Objective: To discuss the influence of recombinant human growth hormone( rh GH) on protein anabolism and immunologic function in elderly thoracic trauma patients. Methods: A total of98 elderly thoracic trauma patients were randomly divided into observation group and control group.Observation group were treated with standard enteral nutrition plus rh GH,and control group were treated with standard enteral nutrition alone. The serum protein levels and immunologic function before and after treatment were compared between the two groups. Results: Before treatment,there was no significant difference of serum albumin level,prealbumin level and serum transferrin level between the two groups( P > 0. 05). After treatment the levels of serum albumin,prealbumin and serum transferrin in observation group were significantly higher than their counterparts before treatment( P < 0. 01),while in control group there was no significant difference( P > 0. 05). After treatment the level of serum albumin,prealbumin and serum transferrin in observation group was significantly higher than their counterparts in control group( P < 0. 01). Before treatment,there was no significant difference in the levels of Ig A,Ig G,Ig M,CD3,CD4,CD8,CD4/CD8 between the two groups( P > 0. 05). After treatment the levels of Ig A,Ig G,Ig M,CD3,CD8,CD4/CD8 in observation group were significantly higher than their counterparts before treatment( P < 0. 01). After treatment,the levels of Ig A,Ig G,Ig M in control group were significantly increased( P < 0. 01),while the levels of CD3,CD4,CD4/CD8 were significantly decreased( P < 0. 01). Conclusions: Rh GH can effectively promote protein synthesis,reduce the protein decomposition rate,increase the immunoglobulin synthesis and secretion,increase the levels of T lymphocyte subsets and improve immune function in the treatment of the elderly thoracic trauma patients.

关键词(KeyWords): 人生长激素;重组蛋白质类;血清白蛋白;老年人;胸外科学;免疫力;免疫球蛋白类
human growth hormone;recombinant proteins;serum albumin;the elderly;thoracic surgery;immunity;immunoglobulin

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作者(Author): 何鹏;周青山;
HE Peng;ZHOU Qingshan;Central Hospital of Xiaogan City;People's Hospital of Wuhan University;

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DOI: 10.19367/j.cnki.1000-2707.2015.03.029

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