贵州医科大学学报

2016, v.41;No.192(09) 1025-1028+1041

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苗药组方熏蒸疗法治疗家兔早期膝骨性关节炎
The Efficacy of Miao Medicine Fumigation Therapy in the Treatment of Rabbit with Early Knee Osteoarthritis

王兴桂;张力文;王政;王贵春;陈盼碧;周汉华;崔瑾;
WANG Xinggui;ZHANG Liwen;WANG Zheng;WANG Guichun;CHEN Panbi;ZHOU Hanhua;CUI Jin;Guiyang Medical college of TCM;Kaili City TCM Hospital;

摘要(Abstract):

目的:观察苗药熏蒸疗法对家兔早期膝骨性关节炎(KOA)的治疗效果。方法:40只新西兰家兔随机分为A组(正常对照组)、B组(模型对照组)、C组(苗药熏蒸组)及D组(蒸馏水熏蒸组),B、C、D组均采用木瓜蛋白酶注射法制造家兔早期KOA模型,A、B两组不予任何治疗,C、D两组在造模同时分别采用苗药组方和蒸馏水进行熏蒸治疗;实验结束时取各组家兔膝关节前正中矢状位股骨内髁内侧软骨标本制片,光镜扫描、电镜观察,采用Mankin’s法进行评分。结果:C组肉眼、光镜及电镜下软骨组织退变病理学改变较B、D组轻,但较A组重;Mankin’s评分显示,C组较B、D组低,较A组高(P<0.01)。结论:苗药熏蒸疗法可以延缓KOA关节软骨的退变,对早期KOA具有较好的治疗作用。
Objective: To observe the efficacy of the Miao medicine fumigation therapy in the treatment of rabbit with early knee osteoarthritis( KOA). Method: 40 New Zealand rabbits were enrolled in this study,and randomly divided into group A( control group),group B( model control group),group C( Miao medicine fumigation group) and group D( water control group). The papain injections method was adopted to establish early KOA rabbit model in group B,group C and group D. Group A and group B received no treatment while group C and group D received Miao medicine fumigation and water fumigation,respectively. After treatment,the medial condylar cartilage samples were taken from the anterior median sagittal femoral medial condyle of the rabbits in each group,and light microscope,scanning electron microscope were used for observation and Mankin 's rating method was used to evaluate. Results: Compared with group B and group D,the cartilage tissue degeneration pathological changes in group C was less severe,but more severe compared with group A. Mankin's rating method showed that Mankin's score in group C was lower than that of group B and group D while higher than that of group A. Conclusion: Miao medicine fumigation therapy can delay the degeneration of articular cartilage of KOA,and has a better therapeutic effect on early KOA.

关键词(KeyWords): 苗药熏蒸疗法;膝骨性关节炎;家兔;光镜;电镜;模型,动物
Miao medicine fumigation therapy;knee osteoarthritis;rabbit;light microscope;electron microscope;model;animal

Abstract:

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基金项目(Foundation): 国家自然基金项目(81260575);; 国家苗药工程技术研究中心项目(2014FU125Q09)

作者(Author): 王兴桂;张力文;王政;王贵春;陈盼碧;周汉华;崔瑾;
WANG Xinggui;ZHANG Liwen;WANG Zheng;WANG Guichun;CHEN Panbi;ZHOU Hanhua;CUI Jin;Guiyang Medical college of TCM;Kaili City TCM Hospital;

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