贵州医科大学学报

2016, v.41;No.195(12) 1455-1458

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米非司酮对围绝经期功能性子宫出血患者的安全性及有效性
Safety and Effectiveness of Mifepristone in Treatment of Dysfunctional Uterine Bleeding during Peri-Menopausal Period

李帅;田巍;
LI Shuai;TIAN Wei;the People's Hospital of Xushui County;

摘要(Abstract):

目的:探讨米非司酮对围绝经期功能性子宫出血患者的安全性及有效性。方法:70例围绝经期功能性子宫出血患者均分为对照组(刮宫术联合去氧孕烯炔雌醇片治疗)及观察组(米非司酮治疗),随访6月,比较两组患者的治疗总有效率及复发率,比较2组患者的子宫内膜厚度、Hb、子宫体积、卵泡刺激素、黄体生成素、雌二醇水平;同时观察两组患者发生恶心、腹泻、皮疹等不良反应发生率。结果:6个月随访结束前,观察组患者治愈率和总有效率高于对照组(P<0.05),治疗前,两组患者子宫内膜厚度、Hb及子宫体积及卵泡刺激素、黄体生成素、雌二醇水平比较,差异无统计学意义(P>0.05);治疗后,两组患者的子宫内膜厚度变薄、Hb水平升高、子宫体积缩小,卵泡刺激素、黄体生成素、雌二醇水平降低,观察组变化更明显,差异有统计学意义(P<0.05);观察组不良反应发生率及复发率显著低于对照组(P<0.05)。结论:米非司酮治疗围绝经期功能性子宫出血效果优于刮宫术联合去氧孕烯炔雌醇片治疗,可显著下调围绝经期功能性子宫出血患者激素水平。
Objective:To explore the safety and efficacy of mifepristone on dysfunctional uterine bleeding during peri menopausal period.Methods:70 cases of peri menopausal dysfunctional uterine bleeding were randomly divided into control group(curettage treatment combined with desogestrel and ethinylestradiol tablets treatment) and observation group(mifepristone treatment).After 6 month follow-up,the total effective rate and recurrence rate were compared between the 2 groups.And endometrial thickness,Hb,uterine volume,follicle stimulating hormone,luteinizing hormone,and estradiol level were also compared between the two groups of patients.Meanwhile,nausea,diarrhea,rash and other adverse reaction incidence were observed and compared between the two groups.Results:Before the end of 6 months of follow-up,the cure rate and total efficiency in the observation group was higher than those of the control group(P<0.05).Before treatment,there were no statistically significant differences in the endometrial thickness,Hb,uterine volume,follicle stimulating hormone,luteinizing hormone,and estradiol level between obervation group and control group.After treatment,the endometrial thickness of was thinner,the level of Hb was increased,the volume of uterus was reduced,and the level of follicle stimulating hormone,luteinizing hormone and estradiol were decreased in the two groups.There were statistically significant differences in these changes between the observation group and the control group.The incidence rate of adverse reaction and recurrence rate in the observation group were significantly lower than their counterparts in control group(P<0.05).Conclusion:Mifeprinstone is better than curettage treatment combined with desogestrel and ethinylestradiol tablets in treatment of dysfunctional uterine bleeding during peri-menopausal period and can significantly decrease hormone levels in patients.

关键词(KeyWords): 米非司酮;围绝经期;功能性子宫出血;子宫内膜厚度;血红蛋白
mifepristone;peri-menopausal period;dysfunctional uterine bleeding;endometrial thickness;hemoglobin

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作者(Author): 李帅;田巍;
LI Shuai;TIAN Wei;the People's Hospital of Xushui County;

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DOI: 10.19367/j.cnki.1000-2707.2016.12.020

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