贵州医科大学学报

2015, v.40;No.176(05) 507-510

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三阴性乳腺癌的超声特征及病理特点
Ultrasonic Features and Clinicopathological Characteristics of Triple-negative Breast Cancer

范宇;范光明;陈霞;江丽;胡小丽;
FAN Yu;FAN Guangming;CHEN Xia;JIANG Li;HU Xiaoli;Guiyang Medical College;Guiyang Maternal and Child Health Care Hospital;Affiliated Hospital of Guiyang Medical College;

摘要(Abstract):

目的:分析三阴性乳腺癌(TNBC)的超声特征及病理特点。方法:手术并经病理学检查证实的281例乳腺癌患者,根据雌激素受体(ER),孕激素受体(PR)和人表皮生长因子受体2(HER2)的表达分为TNBC组(49例)和非TNBC(NTNBC)组(232例),比较两组在常规超声及弹性成像(UE)图像上的差异,分析其病理特点。结果:TNBC组肿瘤组织学分级和腋窝淋巴结转移发生率均显著高于NTNBC组(P<0.05);TNBC组边缘毛刺征、高回声晕、微钙化、后方回声衰减均较NTNBC组少见(P<0.05),TNBC组与NTNBC组彩色多普勒超声表现及UE表现相似(P>0.05)。结论:TNBC病理分级及腋窝淋巴结转移率较高,在二维超声上具有一定的特征性,但在多普勒血流成像及UE表现上与NTNBC无明显差异。
Objective: To analyze the ultrasonic features and clinicopathological characteristics of triple-negative breast cancer( TNBC) and improve TNBC diagnostic accuracy. Methods: According to expression of ER,PR and HER2,281 cases of patients with pathologically confirmed breast cancer were divided into TNBC group( 49 cases) and non-TNBC( NTNBC) group( 232 cases). The differences of conventional ultrasonography,ultrasonic elastography( UE) image were analyzed and compared between TNBC group and NTNBC group. Their pathological features were analyzed. Results:The histological grade and the percentage of lymph node metastasis in TNBC were higher than those in NTNBC( P < 0. 05). Compared with NTNBC group,TNBC group showed less peripheral spicule sign,hyperechoic halo,microcalcification and rear echo attenuation( P < 0. 05). The performance of the two groups in color Doppler ultrasound and UE was similar( P > 0. 05). Conclusion: TNBC patients have higher pathological grade and lymph node metastasis rate,the two-dimensional ultrasonography of TNBC have certain characteristics. The differences of TNBC and NTNBC are not satistically significant in color Doppler ultrasound and UE.

关键词(KeyWords): 乳腺肿瘤;超声检查,乳房;病理学;雌激素受体;孕激素受体;人表皮生长因子受体
breast neoplasms;ultrasonography,breast;pathology;estrogen receptor;progesterone receptor;human epidermal growth factor receptor

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基金项目(Foundation): 贵阳市卫生局科技支撑计划项目,筑卫合同第[2011(710-20)]号

作者(Author): 范宇;范光明;陈霞;江丽;胡小丽;
FAN Yu;FAN Guangming;CHEN Xia;JIANG Li;HU Xiaoli;Guiyang Medical College;Guiyang Maternal and Child Health Care Hospital;Affiliated Hospital of Guiyang Medical College;

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DOI: 10.19367/j.cnki.1000-2707.2015.05.022

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