贵州医科大学学报

2019, v.44;No.222(03) 311-313+325

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合并胃食管反流对支气管哮喘控制及肺功能的影响
Effects of Gastroesophageal Reflux Disease on Asthma and Pulmonary Function

吴建丽;程义局;张世英;
WU Jianli;CHENG Yiju;ZHANG Shiying;Department of Respiratory and Critical Care Medicine,the Affiliated Hospital of Guizhou Medical University;

摘要(Abstract):

目的:探讨合并胃食管反流(GERD)对患者支气管哮喘控制及肺功能的影响。方法:156例支气管哮喘患者,根据是否合并胃食道反流病分为合并GERD组(n=60)及单纯哮喘组(n=96),采用全球哮喘防治创议(GINA)分级评估两组患者哮喘严重程度,比较两组患者用力肺活量(FVC)、第1秒用力呼气容积(FEV1)、呼出50%肺容积最大呼气流量(MEF50%)、MEF75%及呼吸阻力(R20)肺功能指标。结果:合并GERD组患者ACT评分显著低于单纯哮喘组(P <0. 05),合并GERD组重度及中度患者占比显著高于单纯哮喘组,轻度患者占比显著低于单纯哮喘组(P <0. 05);合并GERD组患者PEF、MEF75%、MEF50%显著低于单纯哮喘组、R20显著高于单纯哮喘组(P <0. 05)。结论:合并胃食管反流可降低支气管哮喘患者的肺通气功能及影响哮喘控制水平。
Objective: To investigate the effect of combined gastroesophageal reflux disease( GERD)on symptom control and pulmonary function in patients with asthma. Methods: A total of 156 patients with asthma were divided into asthmatic GERD group( n = 60) and asthma non-GERD group( n = 96)according to whether or not they had gastroesophageal reflux disease. GINA classification evaluation was adopted for the severity of asthma of both groups,comparing pulmonary function parameters of FVC,FEV1 MEF50%,MEF75% and R20 of both groups. Results: The ACT score of asthmatic GERD group was significantly lower than that of asthma non-GERD group( P < 0. 05). Severe and moderate patients in asthmatic GERD group were significantly more than that of asthma non-GERD group,minor patients were obviously less than non-GERD group( P < 0. 05). The PEF,MEF75%and MEF50% of asthmatic GERD group were significantly lower than asthma non-GERD group,R20 was significantly higher than asthma non-GERD group( P < 0. 05). Conclusion: Combined gastroesophageal reflux disease could lower pulmonary function and affect asthma control.

关键词(KeyWords): 胃食管反流;支气管哮喘;肺功能检查;支气管哮喘控制测试
gastroesophageal reflux disease;asthma;lung function test;asthma control test

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基金项目(Foundation): 国家自然科学基金地区科学基金项目(81760016);; 贵州省科学技术厅基金项目[黔科合(2017)0231]

作者(Author): 吴建丽;程义局;张世英;
WU Jianli;CHENG Yiju;ZHANG Shiying;Department of Respiratory and Critical Care Medicine,the Affiliated Hospital of Guizhou Medical University;

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