贵州医科大学学报

2016, v.41;No.188(05) 600-602

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37例儿童糖尿病类型及病因分析
Clinical Analysis of 37 Cases of Juvenile Diabetes

刘毓;陆艳;蔡琴;
LIU Yu;LU Yan;CAI Qin;Department of Endocrine and Genetic Metabolism,Children's Hospital in Guiyang City;

摘要(Abstract):

目的:通过对儿童糖尿病(DM)患者资料的分析,探讨儿童DM的临床特征。方法:收集住院的37例DM患儿的临床表现、实验室检查、治疗转归等资料,分析儿童DM的类型、发病年龄、并发糖尿病酮症酸中毒(DKA)情况及DM相关抗体的变化。结果:37例DM患儿中,1型糖尿病(T1DM)32例(86.5%),2型糖尿病(T2DM)4例(10.8%),新生儿糖尿病(NDM)1例,T1DM的发病率高于T2DM(P<0.05);随着年龄的增长,DM发病率逐渐升高(χ~2=12.25,P<0.05);发病前有感染病史者比无感染病史者DKA的发病率高(P<0.05);T1DM患儿较非T1DM患儿C肽明显下降(P<0.05);T1DM患儿糖尿病自身抗体阳性,其中谷氨酸脱羧酶抗体(GAD-Ab)的敏感性最高(63.7%)。结论:T1DM是儿童DM的主要类型,DKA是儿童T1DM患者就诊的重要原因。
Objective: To investigate the clinical characteristics of juvenile diabetes mellitus( DM)by analyzing clinical data. Methods: Clinical data of 37 cases of DM patients were collected and analyzed,the clinical manifestations( medical history,symptom,physical examination),laboratory and auxiliary examination,treatment method. Results: Among the 37 cases,Type Ⅰ diabetes( T1DM) 32cases( 86. 5%),type Ⅱ diabetes( T2DM) 4 cases( 10. 8%),and 1 cases of neonatal diabetes( NDM). T1 DM incidence rate was higher than T2DM( P < 0. 05); with the development of age,DM incidence rate increased as well( χ~2= 12. 25,P < 0. 05); the incidence rate of diabetic ketoacidosis( DKA) for patients with infection history was higher than those with none( P < 0. 05); C peptide of T1 DM patients significantly decreased than non-T1 DM patients( P < 0. 05); T1 DM patients were measured diabetes autoantibodies,glutamic acid decarboxylase antibody( GAD) positive rate was63. 7%. Conclusions: T1 DM was the major type of juvenile DM,while DKA is the essential factor for T1 DM patients.

关键词(KeyWords): 儿童;糖尿病;发病率;C肽;自身抗体;糖尿病酮症酸中毒
juvenile;diabetes mellitus;incidence rate;C peptide;autoantibody;clinical analysis;diabetic ketoacidosis

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作者(Author): 刘毓;陆艳;蔡琴;
LIU Yu;LU Yan;CAI Qin;Department of Endocrine and Genetic Metabolism,Children's Hospital in Guiyang City;

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DOI: 10.19367/j.cnki.1000-2707.2016.05.028

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