贵州医科大学学报

2018, v.43;No.208(01) 53-56

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同型半胱氨酸及神经肽Y水平与贵阳地区老年人群轻度认知功能障碍的相关性
Relevance Study of Homocysteine,Neuropeptide Y and Elder in Guiyang with Mild Cognitive Impairment

卢丽娜;丁毅;杨冬花;袁露;
LU Lina;DING Yi;YANG Donghua;YUAN Lu;The Cadre Medical Department,Guizhou Provincial People's Hospital;

摘要(Abstract):

目的:探讨贵阳地区老年人同型半胱氨酸(Hcy)及神经肽Y(NPY)水平与轻度认知功能障碍(MCI)的相关性。方法:选取362例贵阳市辖区常住老年(>60岁)体检或就诊者,其中158例MCI患者为病例组,204例非MCI患者作为对照组;收集受试者性别和年龄资料,并于体检当日或就诊次日取空腹静脉血检测血清Hcy、NPY、总胆固醇(TC)、甘油三酯(TG)及低密度脂蛋白胆固醇(LDL-C)水平;采用二元Logistic回归法各分析各指标与MCI的相关性,采用交叉对比法分析各指标的交互作用。结果:病例组Hcy及NPY水平均显著高于对照组(P<0.05),二元Logistic回归分析结果显示Hcy、NPY、TC及LDL-C与老年MCI发病相关(P<0.05),交叉对比法分析发现Hcy分别与NPY、TC及LDL-C在老年MCI发病中具有交互作用(P<0.05)。结论:Hcy及NPY水平升高与贵阳地区老年MCI的发病具有相关性,老年MCI发病可能是多因素共同作用的结果。
Objective: To investigate the relevance of homocysteine( Hcy),neuropeptide Y( NPY)and elderly mild cognitive impairment( MCI) in Guiyang. Methods: 158 elderly patients( > 60 years old) with mild cognitive impairment( MCI) were chosen as case group,204 non-MCI patients without MCI as control group. Collecting general information of patients and fasting venous blood of all patients to test Hcy,NPY,total cholesterol( TC),triglyceride( TG),low density lipoprotein cholesterol( LDL-C). Adopting Dual Logistic Regression assay to analyze relevance between these indexes and MCI; adopting Paired Comparison Method to analyze interaction effect among these indexes. Results:The Hcy and NPY level in MCI group is obviously higher than that of control group( P < 0. 05). Dual Logistic Regression assay indicated that Hcy,NPY,TC and LDL-C were relevant with elderly MCI development( P < 0. 05); Paired Comparison Method indicated that Hcy was interacted with NPY,TC and LDL-C respectively in elderly MCI development( P < 0. 05). Conclusion: The increased level of plasma Hcy and NPY is relevant with elderly MCI in Guiyang. The pathogenesis of MCI development may be the result of multiple factors interaction.

关键词(KeyWords): 认知功能障碍,轻度;老年;同型半胱氨酸;神经肽Y;贵阳
cognitive impairment mild;elderly;homocysteine;neuropeptide Y;Guiyang

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基金项目(Foundation): 贵阳市科技计划项目[筑科合同(20141001)54号]

作者(Author): 卢丽娜;丁毅;杨冬花;袁露;
LU Lina;DING Yi;YANG Donghua;YUAN Lu;The Cadre Medical Department,Guizhou Provincial People's Hospital;

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