贵州医科大学学报

2018, v.43;No.216(09) 1042-1045+1054

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食管鳞癌细胞中程序性细胞死亡因子4与核转录因子的表达
Expression of Programmed Cell Death Factor 4 and Nuclear Transcription Factor in Esophageal Squamous Cell Carcinoma

陈志英;何常;朱璐宏;
CHEN Zhiying;HE Chang;ZHU Luhong;Department of Pathology,Affiliated Hospital of Chengdu University;Department of Pathology,Affiliated Hospital of Guizhou Medical University;

摘要(Abstract):

目的:探讨程序性细胞死亡因子4(PDCD4)与核转录因子(NF-κB)在食管鳞癌中的表达及其与临床病理参数的关系。方法:应用免疫组化Evision法检测PDCD4、NF-κB在58例食管鳞癌组织及配对癌旁正常食管黏膜组织中的表达,分析PDCD4、NF-κB在食管鳞癌中的表达与临床病理参数的关系、食管鳞癌组织中PDCD4及NF-κB表达的关系。结果:PDCD4蛋白在食管鳞癌细胞中的阳性率低于正常组织,差异具有统计学意义(P <0. 01); NF-κB蛋白在食管鳞癌中的阳性率高于正常组织,差异具有统计学意义(P <0. 01);在食管鳞癌中,PDCD4的表达与淋巴结转移有关(P <0. 01),NF-κB表达与淋巴结转移及浸润深度有关(P <0. 01); PDCD4与NF-κB在食管鳞癌中的表达无相关性(P> 0. 05)。结论:PDCD4与NF-κB的异常表达可能与食管鳞癌的发生发展密切相关。
Objective: To investigate the expression of programmed cell death factor 4( PDCD4) and nuclear transcription factor( NF-κB) in esophageal squamous cell carcinoma and its relationship with clinicopathological parameters. Methods: Expression of PDCD4 and NF-κ B in 58 cases of esophageal squamous cell carcinoma and adjacent normal esophageal mucosa was detected by immunohistochemical Evision. The relationship between the expression of PDCD4 and NF-κB in esophageal squamous cell carcinoma and clinicopathological parameters,and the expression of PDCD4 and NF-κB in esophageal squamous cell carcinoma were analyzed. Results: The positive rate of PDCD4 protein in esophageal squamous cell carcinoma was lower than that in normal tissues,and the difference was statistically significant( P < 0. 01). The positive rate of NF-κB protein in esophageal squamous cell carcinoma was higher than that in normal tissue,and the difference was statistically significant( P < 0. 01). In esophageal squamous cell carcinoma,expression of PDCD4 was associated with lymph node metastasis( P <0. 01),and expression of NF-κB was related to lymph node metastasis and depth of invasion( P <0. 01). There was no correlation between the expression of PDCD4 and NF-κB in esophageal squamous cell carcinoma( P > 0. 05). Conclusion: The abnormal expression of PDCD4 and NF-κB is closely related to the occurrence and development of esophageal squamous cell carcinoma.

关键词(KeyWords): 程序性细胞死亡因子4;核转录因子;食管肿瘤;癌,鳞状细胞
programmed cell death factor 4;nuclear transcription factor;esophageal neoplasms;carcinoma,squamous cell

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基金项目(Foundation): 贵州省科技厅基金项目(E2010-4)

作者(Author): 陈志英;何常;朱璐宏;
CHEN Zhiying;HE Chang;ZHU Luhong;Department of Pathology,Affiliated Hospital of Chengdu University;Department of Pathology,Affiliated Hospital of Guizhou Medical University;

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