贵州医科大学学报

2013, (01) 1-4

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贵阳市原发性肝癌危险因素的病例对照研究
A Case-control Study on Risk Factors of Primary Hepatocellular Carcinoma in Guiyang City

陈莎莎;赵雪珂;程明亮;谭家武;王文志;张权;罗新华;王文玲;
CHEN Shasha1,ZHAO Xueke1,CHENG Mingliang1,TAN Jiawu1,WANG Wenzhi1, ZHANG Quan1,LUO Xinhua2,WANG Wenling3(1.Department of Infectious Diseases,the Affiliated Hospital of Guiyang Medical College,Guiyang 550004,Guizhou,China; 2.Department of Infectious Diseases,People's Hospital of Guizhou Province,Guiyang 550002,Guizhou,China; 3.Department of Radiation Oncology,Guizhou Provincial Cancer Hospital,Guiyang 550001,Guizhou,China)

摘要(Abstract):

目的:探讨贵阳市原发性肝癌主要危险因素。方法:采用成组病例对照研究,对3家医院的120例肝细胞癌患者和199例对照进行一般情况、饮酒史、吸烟史、既往疾病史、家族史、经济状况及其他生活习惯等调查;应用非条件logistic回归分析,通过比值比(OR)和95%可信区间(95%CI)进行评估,探讨与贵阳市原发性肝癌发生相关的主要危险因素。结果:5年前经济状况、肝癌家族史、吸烟、慢性肝病史、乙型肝炎病毒感染、饮酒在病例组和对照组间的差异有显著性,其OR值分别为0.324、5.185、2.649、2.554、10.961、3.345,95%CI分别为0.159~0.661、2.284~11.772、1.162~6.040、1.205~5.415、5.240~22.925、1.696~6.594。结论:肝癌家族史、吸烟、慢性肝病史、乙型肝炎病毒感染、饮酒可能是贵阳市肝癌发生的危险因素,5年前经济状况良好可能是其保护因素。
Objective: To determine the main risk factors of primary hepatocellular carcinoma(PHC) in Guiyang city.Methods: Case-control study was adopted to investigate 120 PHC patients and 199 controls by using a questionnaire to obtain information,including general situation,drinking history,smoking history,medical history,family medical history,economic conditions and other habits.The main related-factors were analyzed with non-conditional logistic regression model and evaluated by odds ratio(OR) and 95% confidence interval(95%CI).Results: There are significant differences between PHC cases and controls in terms of economic status in past 5 years(OR=0.324),family PHC history(OR=5.185),cigarette smoking(OR=2.649),chronic liver disease(OR=2.554),HBV infection(OR=10.961),and alcohol drinking(OR=3.345),and 95%CI were 0.159~0.661、2.284~11.772、1.162~6.040、1.205~5.415、5.240~22.925、1.696~6.594 respectively.Conclusions: Family history of liver cancer,cigarette smoking,chronic liver disease,HBV infection,and alcohol drinking might be main risk factors of PHC in Guiyang city and better economic status in past 5 years is one of the protective factors for PHC patients.

关键词(KeyWords): 肝肿瘤;癌;危险因素;病例对照研究
liver neoplasms;carcinoma;risk factors;case-control studies

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基金项目(Foundation): 973计划前期研究专项(2011CB512114)

作者(Author): 陈莎莎;赵雪珂;程明亮;谭家武;王文志;张权;罗新华;王文玲;
CHEN Shasha1,ZHAO Xueke1,CHENG Mingliang1,TAN Jiawu1,WANG Wenzhi1, ZHANG Quan1,LUO Xinhua2,WANG Wenling3(1.Department of Infectious Diseases,the Affiliated Hospital of Guiyang Medical College,Guiyang 550004,Guizhou,China; 2.Department of Infectious Diseases,People's Hospital of Guizhou Province,Guiyang 550002,Guizhou,China; 3.Department of Radiation Oncology,Guizhou Provincial Cancer Hospital,Guiyang 550001,Guizhou,China)

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