贵州医科大学学报

1990, (04) 270-272

[打印本页] [关闭]
本期目录(Current Issue) | 过刊浏览(Past Issue) | 高级检索(Advanced Search)

4-(4-羟基苯亚甲氨基)丁酸酯类衍生物的合成
Synthesis of 4-[(4 -Hydrophenyl) Methylene Aminol Butyrates

袁牧;钟裕国;庞其捷;李正化;
Yuan Mu, et al Department of Pharmaceutical Chemistry

摘要(Abstract):

作者以4-羟基苯甲醛作为Υ-氨基丁酸的亲脂性载体,设计并合成了3个4-(4-羟基苯亚甲氨基)丁酸酯类衍生物作为抗惊厥化合物供药理筛选。所合成的化合物尚未见文献报道。
Most studies have indicated that γ-aminobutyric acid (GABA) plays a role inthe pathophysiology of epilepsy GABA increase the threshold of convulsion when it was administered locally in the brain of dog.Under physiological condition GABA poorly crosses the blood-brain barrier, so it is not effective when administered orally.It is likely that a nontoxic GABA mimetic which easily enters the brain will have useful therapeutic properties with this in mind, we have designed and synthesized 3 derivatives of γ-aminobutyric acid with an imine like (Schiff base) to a lipophilic carrier in order to facilitate that the passage of GABA across the blood-brain barrier (Ⅱa, Ⅱb, Ⅱc),These Compounds have not been reported, their chemical structure were primary identified with IR Spectra

关键词(KeyWords): γ-氨基丁酸衍生物;Schiff;碱型;γ-氨基丁酸酯
derivative of γ-aminobutyric acid;Schiff bases of γ-aminobutyrates

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 袁牧;钟裕国;庞其捷;李正化;
Yuan Mu, et al Department of Pharmaceutical Chemistry

Email:

DOI: 10.19367/j.cnki.1000-2707.1990.04.008

文章评论(Comment):

序号(No.) 时间(Time) 反馈人(User) 邮箱(Email) 标题(Title) 内容(Content)
反馈人(User) 邮箱地址(Email)
反馈标题(Title)
反馈内容(Content)
扩展功能
本文信息
服务与反馈
本文关键词相关文章
本文作者相关文章
中国知网
分享