贵州医科大学学报

2008, No.130(01) 52-54

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原发性高血压左室肥厚患者的尿酸与性别相关性研究
A Study on the Sex Association of Serum Uric Acid and Ieft Ventricular Hypertrophy in Hypertension Patients

刁晓艳;谢萍;
DIAO Xiaoyan1, XIE Ping2(1. Department of Cardiology, The Affiliated Hospital of Guiyang Medical College, Guiyang 550004, Guizhou, China; 2. Department of Internal Medicine, The 4th People’s Hospital of Liupanshui, Liupanshui 553000, Guizhou, China)

摘要(Abstract):

目的:探讨原发性高血压患者左室肥厚(LVH)与尿酸(UA)的关系是否具有性别差异。方法:对60例高血压患者测定血脂、UA,超声心动图测定心脏各腔室内径,计算左室质量指数(LVMI)。采用多元线性回归及相关分析法分析UA与左室肥厚的关系及其性别差异。结果:所有患者UA与LVMI线性相关(P<0.05),按性别分类后再进行相关分析,男性患者UA明显高于女性患者(P<0.05),但仅女性患者的UA与LVMI密切相关(P<0.01)。结论:UA与女性原发性高血压患者左室肥厚的发生、发展有一定的关系。
Objective: To investigate whether sex difference contributes to level of serum uric acid (UA) and left ventricular hypertrophy (LVH) in patients with hypertension. Methods: The left ventricular mass index (LVMI) of 60 participants with essential hypertension was checked and calculated with echocardiography. Serum UA and lipid of the patients were tested. The data collected were analyzed with multiple linear regression and correlation analysis. Results: The UA was significantly independently associated with LVMI (t=2.037,P= 0.04) in all patients. Serum UA was significantly higher in men than in women (P<0.05). Correlation analysis revealed that the LVMI was significantly associated with serum UA in women, but not in men. Conclusions: There is some relation between serum UA and occurrence and progress of LVH in female patients with essential hypertension.

关键词(KeyWords): 尿酸;肥大,左心室;高血压;性别因素
uric acid; hypertrophy, left ventricular; hypertension; sex factors

Abstract:

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作者(Author): 刁晓艳;谢萍;
DIAO Xiaoyan1, XIE Ping2(1. Department of Cardiology, The Affiliated Hospital of Guiyang Medical College, Guiyang 550004, Guizhou, China; 2. Department of Internal Medicine, The 4th People’s Hospital of Liupanshui, Liupanshui 553000, Guizhou, China)

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DOI: 10.19367/j.cnki.1000-2707.2008.01.019

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