贵州医科大学学报

1997, (04)

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晚期正常妊娠及妊高征患者血浆NO及内皮素变化的临床意义
The Clinical Significance of Plasma Nitric Oxide and Endothelin Level in Patients of Normal Late Pregnant Women and Pregnancy Induced Hypertension

袁筑华,张春,罗锦
Yuan Zhuhua,et alDepartment of Gynecology and Obstetrics,Guiyang Medical College

摘要(Abstract):

用亚硝酸盐法及放射免疫分析法对32例正常晚期妊娠妇女,28例妊高征患者及20例育龄非孕妇女的血浆一氧化氮(NO)和内皮素(ET)进行测定。结果:(1)正常晚期妊娠妇女血浆NO含量明显高于育龄非孕妇女(P<0.01),但血浆ET水平两者差异无显著性(P>0.05)。(2)妊高征患者血浆NO含量明显低于正常晚期妊娠妇女和育龄非孕妇女(P<0.01),而血浆ET水平均高于正常晚期妊娠妇女和育龄非孕妇女(P<0.01);妊高征组血浆NO含量降低与ET的增高综合评分呈显著负相关(r=-0.47,P<0.01)。提示:妊娠期NO合成增加对维持正常妊娠具有重要意义;妊高征的发生可能与NO的合成减少、ET的异常增高有关。
To investigate the relationship of nitric oxide (NO) and endothelin (ET) level between normal late pregnant women and pregnancy induced hypertension (PIH).The plasma level of NO and ET in 32 cases of normal late pregnant women and 28 cases of PIH and 20 cases of nonpregnant women were measured and compared by Greiss reagent and radioimmunoassay.The results show:(1)The NO level of normal late pregnant groups were significantly higher than normal nonpregnant women (P<001),but the level of ET was no significantly different between the two groups (P>005).(2)The No level of PIH was significantly lower than that of normal late pregnant and normal nonpregnant women (P<001).But the ET level was significantly higher than that of normal late pregnant and normal nonpregnant women (P<001).There was a significantly negative relation between the plasma NO and ET level in PIH (r=-047,P<001).The above results suggest that:Synthesis of NO might play an important role in normal pregnancy.The decrease of NO synthesis and in crease of ET may be one of the important factor responsible for PIH.

关键词(KeyWords): 一氧化氮,妊高征,内皮素
nitric oxide;endothelin;pregnancy induced hypertension

Abstract:

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作者(Author): 袁筑华,张春,罗锦
Yuan Zhuhua,et alDepartment of Gynecology and Obstetrics,Guiyang Medical College

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DOI: 10.19367/j.cnki.1000-2707.1997.04.015

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