贵州医科大学学报

1995, (02)

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氯氮平和氯丙嗪对210例Ⅰ、Ⅱ型精神分裂症的疗效观察
Clinical Efficacy in Treatment of 210 Cases Ⅰ,Ⅱ Type Schizophrenia with Clozapine and Chlorpromazine

罗环跃,刘红霞
Luo Huanyue,et al(Anning Hospital of Guizhou)

摘要(Abstract):

用氯氮平、氯丙嗪治疗Ⅰ、Ⅱ型精神分裂210例。分别在治疗前、后2、4、8周使用简明精神病量表(BPRS)、阳性症状量表(SAPS)、阴性症状量表(SANS)、临床总体印象量表(CGI)和副反应量表(TESS)进行盲式评分。结果显示:氯氮平对Ⅰ型、Ⅱ型精神分裂症均有较好疗效(P<0.01)。氯丙嗪对Ⅰ型疗效较好(P<0.01),对Ⅱ型疗效较差(P>0.05)。
Two hundred and ten cases of Ⅰ,Ⅱ type schizophrenia were treated with clozapine and chlorpromazine. The petients were divided into the Ⅰ type schizophreniz and Ⅱ type schizophrenia according to the rating results of SAPS,SANS and Andreasen's method, then patients were divided into the group that were trated with clozapine(49 cases of Ⅰ type,42 cases of Ⅱtype) and the group that were treated with chlorpromazine (64 cases of Ⅰ type,55 cases of Ⅱtype)by random.All of patients were rated blindly on BPRS,CGI,SAPS,SANS and TESS by two trained psychopathists before the treatment and in second, fourth and eighth week after the treatment.The resuLts suggest:clozapine is effective and the efficacy is equal between Ⅰ type and Ⅱ type schizophrenia(P<0.01).Chlorpromazine is effective to Ⅰ type schizophrenia(P<0.01), but it fails to respond to Ⅱ type schizophrenia(P>0.05). The efficacy, use in clinical treatment,mechanism of action and side effect of clozapine have been discussed.

关键词(KeyWords): 精神分裂症,氯氮平,氯丙嗪
schizophrenia;clozapine;chlorpromazine

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作者(Author): 罗环跃,刘红霞
Luo Huanyue,et al(Anning Hospital of Guizhou)

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