吴晓,戴大英,姜淑芬,肖开棋
Wu Xiao,et alDepartment of Pathology,Affiliated Hospital of Guiyang Medical College

• 1:贵阳医学院附院病理科

摘要(Abstract)：

采用免疫组化方法，观察ｂｃｌ－２（Ｂｃｅｌｌｙｍｐｈｏｍａ－２）基因产物在多形性腺瘤及其恶变组织中的表达与分布，以图像分析仪进行计数分析。结果显示肿瘤组织中以导管样上皮细胞、粘液样细胞以及软骨样细胞的阳性表达较高，而鳞状上皮团块中，ｂｃｌ－２表达极低。各组阳性病例比例：对照组５例慢性诞腺炎为８０％（４／５），１５例多形性腺瘤为８０％（１３／１５），７例多形性腺瘤恶性病变为８６％（６／７）。图像分析仪计数阳性细胞显示慢性诞腺炎为５％，多形性腺瘤为４２％，而恶性病变为５７％，统计与分析表明良性及恶性多形性腺瘤与对照组比较，差异有显著性（Ｐ＜０．０５），而良性和恶性组间，差异无显著性（Ｐ＞０．０５）。
bcl2 is a apoptosissuppressing oncogene,and plays an important role in oncogenesis.bcl2 protein was detected by immunohistochemistry in 5 cases with chronic sialadenitis,15 cases (benign) and 7 cases (malignant) of pleomorphic adenoma of salivary glands.The results showed that bel2 expression in 4/5 cases with chronic sialadenitis,13/15 cases with benign and 6/7 cases with malignant pleomorphic adenoma were observed,respectively.Image analysis indicated 5%,42%,and 57% of total cells were positive for bcl2 in three groups,respectively.These findings suggest bcl2 gene may play an important role in developmen of pleomorphic adenomas.

关键词(KeyWords)： 多形性腺瘤,恶性多形性腺瘤,B细胞淋巴瘤-2基因蛋白
pleomorphic adenoma;malignant pleomorphic adenoma;Bcell lymphoma2

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 吴晓,戴大英,姜淑芬,肖开棋
Wu Xiao,et alDepartment of Pathology,Affiliated Hospital of Guiyang Medical College

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DOI: 10.19367/j.cnki.1000-2707.1997.04.005

参考文献(References)：

• 1TsujimotoY，etal．Involvementofthebcl－2geneinhumanfolicularlymphoma．Sience，1985，228：14402HockenbergDM，etal．Bcl－2fumetionsissanan－tioxidantpathwaytopreventapptosis．Cel，1993，75：241

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