贵州医科大学学报

1997, (04)

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多形性腺瘤及恶变组织中bal-2表达
Expression of bcl2 in Benign and Malignant Pleomorphic Adenoma of Salivary Glands

吴晓,戴大英,姜淑芬,肖开棋
Wu Xiao,et alDepartment of Pathology,Affiliated Hospital of Guiyang Medical College

摘要(Abstract):

采用免疫组化方法,观察bcl-2(Bcellymphoma-2)基因产物在多形性腺瘤及其恶变组织中的表达与分布,以图像分析仪进行计数分析。结果显示肿瘤组织中以导管样上皮细胞、粘液样细胞以及软骨样细胞的阳性表达较高,而鳞状上皮团块中,bcl-2表达极低。各组阳性病例比例:对照组5例慢性诞腺炎为80%(4/5),15例多形性腺瘤为80%(13/15),7例多形性腺瘤恶性病变为86%(6/7)。图像分析仪计数阳性细胞显示慢性诞腺炎为5%,多形性腺瘤为42%,而恶性病变为57%,统计与分析表明良性及恶性多形性腺瘤与对照组比较,差异有显著性(P<0.05),而良性和恶性组间,差异无显著性(P>0.05)。
bcl2 is a apoptosissuppressing oncogene,and plays an important role in oncogenesis.bcl2 protein was detected by immunohistochemistry in 5 cases with chronic sialadenitis,15 cases (benign) and 7 cases (malignant) of pleomorphic adenoma of salivary glands.The results showed that bel2 expression in 4/5 cases with chronic sialadenitis,13/15 cases with benign and 6/7 cases with malignant pleomorphic adenoma were observed,respectively.Image analysis indicated 5%,42%,and 57% of total cells were positive for bcl2 in three groups,respectively.These findings suggest bcl2 gene may play an important role in developmen of pleomorphic adenomas.

关键词(KeyWords): 多形性腺瘤,恶性多形性腺瘤,B细胞淋巴瘤-2基因蛋白
pleomorphic adenoma;malignant pleomorphic adenoma;Bcell lymphoma2

Abstract:

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作者(Author): 吴晓,戴大英,姜淑芬,肖开棋
Wu Xiao,et alDepartment of Pathology,Affiliated Hospital of Guiyang Medical College

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DOI: 10.19367/j.cnki.1000-2707.1997.04.005

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