贵州医科大学学报

2008, No.133(04) 377-379+384

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转移抑制基因MKK4在大肠癌中的表达与其生物学行为及预后的关系
Expression of MKK4 in Colorectal Carcinoma and Its Relationship with Biological Behavior and Prognosis of the Tumor

王菊芳;何常;陈志英;李珀;钟愉;
WANG Jufang,HE Chang,CHEN Zhiying,LI Po,ZHONG Yu (Department of Pathology,Guiyang Medical College,Guiyang 550004,Guizhou,China)

摘要(Abstract):

目的:检测有丝分裂素激活蛋白激酶激酶4(Mitogen-activated protein Kinase Kinase 4,MKK4)在大肠癌中的表达与其生物学行为及预后的关系。方法:应用免疫组织化学Envision二步法对58例大肠癌和20例大肠黏膜慢性炎症MKK4表达进行检测。结果:大肠癌组织中MKK4阳性表达率为75.9%,慢性炎症组织中MKK4阳性表达率为100%,大肠癌MKK4阳性表达率较慢性炎症组织低,差异有显著性(P<0.05);大肠癌组织中MKK4阳性表达率与患者年龄、性别、肿瘤部位及大小无关(P>0.05),与有无淋巴结转移、临床分期、浸润深度及生存期有关(P<0.05)。结论:MKK4可能在大肠癌侵袭转移的发展过程中具有重要作用,与患者预后相关。
Objective: To investigate the expression of mitogen-activated protein kinase kinase 4(MKK4)in colorectal carcinoma and its relationship with the biological behavior and prognosis of the tumor.Methods: MKK4 expression in tissue specimens of 58 cases of colorectal carcinoma and 20 cases of chronic inflammatory were detected by using immunohistochemistry(IHC) method,and Envision two-step staining method.Results: Positive rate of MKK4 protein in colorectal carcinoma tissues(75.9 %) was lower than that in chronic inflammatory tissues(100 %).The difference was significant(P<0.05).MKK4 expressions in carcinoma tissues correlated with lymph node metastasis(P<0.05),Dukes stage(P<0.05),invasive depth(P<0.05),and survival time(P<0.05),but not with age,gender,location or tumor volume(P>0.05).Conclusions: MKK4 may play an important role in the progression,metastasis of human colorectal carcinoma,and closely correlates with patients' prognosis.

关键词(KeyWords): 基因,肿瘤抑制;癌;大肠;有丝分裂素激活蛋白激酶激酶类;病理学,临床;预后
genes,tumor suppressor;carcinoma;intestine,large;mitogen-activated protein kinase kinases;Pathology,clinical;prognosis

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作者(Author): 王菊芳;何常;陈志英;李珀;钟愉;
WANG Jufang,HE Chang,CHEN Zhiying,LI Po,ZHONG Yu (Department of Pathology,Guiyang Medical College,Guiyang 550004,Guizhou,China)

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DOI: 10.19367/j.cnki.1000-2707.2008.04.016

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