贵州医科大学学报

2007, (05) 471-473+477

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组织蛋白酶B和基质金属蛋白酶-9在喉癌中的表达
Expression of Cathepsin B and MMP-9 in Laryngeal Squamous Cell Carcinoma and Its Significance

田禾;陈乾美;卓贤露;常敖霜;
TIAN He,CHEN Qianmei,ZHUO Xianlu,CHANG Aoshuang(Department of Otorhinolarynglogy,The Affiliated Hospital of Guiyang Medical College,Guiyang 550004,China)

摘要(Abstract):

目的:通过检测人喉癌组织中组织蛋白酶B(Cathepsin B,CB)和基质金属蛋白酶-9(MMP-9)的表达,探讨其在喉癌中的表达及其与淋巴结转移的关系。方法:采用免疫组织化学(S-P)法,检测41例人喉癌标本、20例正常喉黏膜标本(对照组)中CB和MMP-9的表达。结果:CB和MMP-9在喉癌组织中的表达高于对照组(P<0.01),在有淋巴结转移的喉癌组织中的表达高于无淋巴结转移喉癌组织(P<0.05);CB和MMP-9的表达之间存在明显的相关性。结论:喉癌中CB、MMP-9的表达可能是癌肿发生、生长和浸润转移的重要因素,可作为判断肿瘤恶性程度和预后的重要指标。
Objective: To investigate the expression of cathepsin B,matrix metalloproteinase-9(MMP-9) in laryngeal carcinoma,and its correlation with lymph node metastasis.Methods:Using immunohistochemistry method,the expressions of these two proteases in 41 cases of laryngeal cancer and 20 cases of normal laryngeal cavity mucosa(as control) were examined.Results: The expression of cathepsin B and MMP-9 in laryngeal carcinoma tissues were higher than those in control(P<0.05);and their expressions were even higher in laryngeal carcinoma cases with lymph node metastasis than those in cases without metastasis(P<0.05).There was also a significant correlation in staining intensity between cathepsin B and MMP-9.Conclusions:The expressions of cathepsin B and MMP-9 increase in laryngeal carcinoma which might be important factors involved in carcinogenesis,tumor development,invasion and metastasis.Their expression can be used as predictors of malignant behavior and prognosis of laryngeal carcinoma.

关键词(KeyWords): 癌;喉;组织蛋白酶B;基质金属蛋白酶;免疫组织化学;肿瘤转移;淋巴结
carcinoma;laynx;cathepsin B;matrix metalloproteinase;immunohistochemistry;neoplasm metastasis;lymph nodes

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基金项目(Foundation): 贵州省优秀人才省长基金[2002-3]

作者(Author): 田禾;陈乾美;卓贤露;常敖霜;
TIAN He,CHEN Qianmei,ZHUO Xianlu,CHANG Aoshuang(Department of Otorhinolarynglogy,The Affiliated Hospital of Guiyang Medical College,Guiyang 550004,China)

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