贵州医科大学学报

1985, (02) 113-116

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健康个体外周血液自然杀伤细胞活性的研究
NATURAL KILLER CELL—MEDIATED CYTOTOXICITY IN NORMAL INDIVIDUALS

李永琴;庄宗杰;桂华珍;刘家骝;
Li Yongqin (DePartment of Pathology)

摘要(Abstract):

<正> 自然杀伤细胞(NK细胞)是一类重要的非特异免疫细胞,涉及机体免疫监视,特别是能抗肿瘤,病毒还涉及器官移植排斥反应。近年来对NK细胞活性的研究日超广泛。我们采用~(125)IUdR标记K562靶细胞的同位素释放试验法研究了355例健康个体外周血NK细胞活性。现将结果报导如下。实验分组一、年龄与NK细胞活性(1) 二、性别与NK细胞活性比较男性健康个体193例和女性健康个体162例NK细胞活性。三、月经与NK细胞活性 1、正常月经与绝经妇女NK细胞活
Taking K562 as the target cell we have observed the natural killer activity of mononuclear cells from the peripheral blood of 355 normal subjects. NK cells from different individuals express different reactivity to K542 but the NK activity of same individuals was very steady during a long time, In the males the values of aged group (>60 years old) and of 1-17 year old group were compared with that of adult group (18-59 year old) showing signficant difference (P<0.05) In females the value of adult group was higher than other groups but no showing significant diffenrece (P>0.05) , These results sugges that the immunity of old persons has reduced with the reduction of immune surveilance, In these study the values of adult females was lower than that of the same age group males. The activity varies during the menstrual cycle showing a peak in mid-mens- trual perod suggesting that natural killer activity may be modulated by hor- mons.

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作者(Author): 李永琴;庄宗杰;桂华珍;刘家骝;
Li Yongqin (DePartment of Pathology)

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