贵州医科大学学报

2004, (02) 118-120+125

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病毒性乙型肝炎患者Th细胞亚群与ALT、IgG、C_3的相关性研究
A Study on the Correlation between Thcell-subtypes and ALT, IgG, and C_3 in Patients with Hepatitis B

余红岚,刘若英,宋静芳,胡大忠,倪飞燕
YU Hong-lan 1, LIU Ruo-ying 1, SONG Jing-fang 1, HU Da-zhong 2, NI Fei-yan 3 (1. Guiyang First People’s Hospital, Guiyang 550002, China; 2.Guiyang 5th People’s Hospital, Guiyang 550004, China; 3. Health Care Team, Fireman Branch of Guiyang City, Guiyang 550004, China)

摘要(Abstract):

目的 :探讨慢性重型乙型肝炎、慢性乙型肝炎、乙型肝炎无症状病毒携带者血清IL 2、IFN γ、IL 4与ALT、IgG、C3 的关系 ,了解乙肝患者肝损伤的病理机制。方法 :6 4份血清用ABC ELISA法测定IL 2、IL 4、IFN γ ,用透射比浊法测定IgG、C3 ,用酶法测定ALT。结果 :(1)血清ALT、IgG水平在无症状病毒携带者、慢性肝炎、慢性重型肝炎中水平逐次增高 ,C3 水平却依此降低 ;(2 )慢性重型肝炎ALT与IL 2、IFN γ有正相关性、与IL 4无显著相关性 ,IgG与IL 4无显著相关性 ,C3 与IL 2、IFN γ负相关 ;慢性肝炎ALT与IL 4、IL 2、IFN γ均无显著相关性 ,IgG与IL 4呈正相关、而与IL 2、IFN γ无相关性 ;(3)动态观察无症状病毒携带者 6月 ,测定以上 5个指标 3次 ,3次结果 5个指标均无显著性差异。结论 :慢性重型肝炎以Th1类细胞因子占优势 ,慢性肝炎以Th2类细胞因子占优势 ,进一步证实肝功能损害的严重程度和Th1的免疫应答的强度有关 ,IgG和C3 随着病情进展而变化。
Objective: To detect the concentrations of partial Th1/Th2 cell factors and to analyze the relationship of ALT, IgG, and C 3 with interleukin 2,4 (IL-2, IL-4), and interferen-γ(IFN-γ) in patients with different clinical types of hepatitis B. Methods: Sixty-four samples of serum were collected from patients with hepatitis B belonging to different clinical types, and IL2,IL4, and IFN-γ were detected by ABC-ELISA method. The immunoglobulin G and complement 3 were also detected by immunoturbidimetry. Results: The IgG levels in chronic sever hepatitis B (CSH) and chronic hepatitis B (CH) were higher than thoes of control group (P<0.01, P<0.05). The levels of C 3 in CSH and CH groups were lower than those of control group (P<0.01, P<0.05). The levels of IgG, and C 3 did not change in asymptomatic hepatitis B group. The level of ALT correlate with levels of IL-2 and IFN-γ in CSH group. The level of IgG correlated with IL-4(P<0.01). Conclusions: Th1 cytokines correlate with hepatic inflammation activity of chronic hepatitis B. The activation of Th1 seems link with injury of liver cells. Th2 cells might associate with the persistence of HBV infection.

关键词(KeyWords): 肝炎,乙型,慢性;白细胞介素2;白细胞介素4;干扰素Ⅱ型;补体3;丙氨酸转氨酶;免疫球蛋白G
hepatitis B,chronic; interleukin-2; interleukin-4; interferon type Ⅱ; complement 3; alanine transaminase; immunolglobulin G

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作者(Author): 余红岚,刘若英,宋静芳,胡大忠,倪飞燕
YU Hong-lan 1, LIU Ruo-ying 1, SONG Jing-fang 1, HU Da-zhong 2, NI Fei-yan 3 (1. Guiyang First People’s Hospital, Guiyang 550002, China; 2.Guiyang 5th People’s Hospital, Guiyang 550004, China; 3. Health Care Team, Fireman Branch of Guiyang City, Guiyang 550004, China)

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DOI: 10.19367/j.cnki.1000-2707.2004.02.011

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