贵州医科大学学报

1988, (02) 218-222

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异防己碱与汉防已碱降压作用比较研究
COMPARATIVE STUDY ON ISOTETRANDRINE AND TETRANDRINE IN RESPECT OF EFFECT OF LOWERING BLOOD PRESSURE

查力;杨桂萍;李庆;许金池;
Cha Li,Guizhou Geriatrics Institute

摘要(Abstract):

本文报道异防己碱与汉防己碱降压作用的比较研究。结果表明:两降压药作用相似,对犬、大白鼠的降压作用有明显的量—效关系,且降压作用与抑制心肌收缩力、减慢心率等呈正相关。异防己碱降压作用可能与拮抗 Ca~(+2)内流有关。
Isotetrandrine(IT)is an alkaloid isolated from a root of Mahamin beali.Its effect on blood pressure(BP),myocardial contraction(MC),heart rate(HR) and respiration in anesthetized dogs and rats were studied and compared with hose of tetrandrine(T)。With intravenous(iv)injection of IT or T in dogs or rats,the BP decreased rapidly.In dogs,iv injection of IT (4,8,12mg/kg) reduced the BP by 14%,30%,and 48%,while of T reduced by 7%,28%, and 54% respectively.Both showed a dose-dependent effect of lowering BP. In rats,intraduodenal injection of IT or T also decreased the BP markedly. iv of IT or T resulted in a marked fall of BP accompanied by inhibited MC, HR and respiration amplitude,but the effect of T was more marked.These results suggest that the effect of lowering BP of IT is comparable to that of T,and it is attributed to the blockade of calcium channels.Their negativ cardiac inotropic effect and chronotropic effect may account for the action o lowering BP.The acute LD_(50) of IT in mice is 165.75mg/kg intraperitoneal (ip)injection.

关键词(KeyWords): 异防己碱;汉防己碱;降压剂;心肌收缩;心率;半数致死量
lsotetrandrine;Tetrandrine;Antihypertensive agent Myocardial;contraction;Heart rate;LD_(50)

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作者(Author): 查力;杨桂萍;李庆;许金池;
Cha Li,Guizhou Geriatrics Institute

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DOI: 10.19367/j.cnki.1000-2707.1988.02.023

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