查艳,周力,刘琦,张永宏,马启玲
ZHA Yan 1, ZHOU Li 1, LIU Qi 1, ZHANG Yong-hong 1, MA Qi-ling 1 (Department of Digestive Medicine, The Affiliated Hospital of Guiyang Medical College, Guiyang 550004, China)

• 1:贵阳医学院附院消化内科
• 2:贵阳医学院附院消化内科
• 3:贵阳医学院附院消化内科
• 4:贵阳医学院附院消化内科

摘要(Abstract)：

目的:研究反复短时血液滤过(RSVVH)治疗重症急性胰腺炎(SAP)的疗效及机制。方法:47例 SAP患者随机分为血滤组(HF组)24例和非血滤组(NHF组)23例,观察RSVVH后促炎细胞因子TNFα,IL 1β, IL 6,IL 8的动态变化。结果:第1次血滤结束24h,HF组各细胞因子的含量较入院时和NHF组有所下降,但P >0.05;血滤结束第7天,HF组促炎细胞因子较入院时(P<0.01)和NHF组(P<0.05)有显著降低,存活率HF 组为91.7%,NHF组为73.9%。结论:重症急性胰腺炎早期采用RSVVH疗法,有利于清除体内过多的促炎细 胞因子,提高生存率。
Objective: To estimate the effects of therapy of repeated short veno-venous hemofiltration (RSVVH) on severe acute pancreatitis (SAP). Methods: 47 SAP patients were randomly divided into hemofiltration group (HF, 24 cases) and non-hemofiltration group (NHF, 23 cases). The concentrations of serum pro-inflammatory cytokines (TNFα,IL-1β,IL-6,IL-8) in different groups were determined at different observation points. Results: At the 24 th hour post-RSVVH, the levels of pro-inflammatory cytokines decreased gradually. The levels of 4 cytokines on the 7 th day after RSVVH in HF group were significantly lower than those in NHF group (P<0.05), and were lower than those before the RSVVH (P<0.01). The survival rates of group HF and group NHF were 91.7% and 73.9% respectively. Conclusions: RSVVH therapy could decrease the concentrations of 4 cytokines and increase the patient survival rate.

关键词(KeyWords)： 胰腺炎;血液滤过;细胞因子类
pancreatitis; hemofiltration; cytokines

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 查艳,周力,刘琦,张永宏,马启玲
ZHA Yan 1, ZHOU Li 1, LIU Qi 1, ZHANG Yong-hong 1, MA Qi-ling 1 (Department of Digestive Medicine, The Affiliated Hospital of Guiyang Medical College, Guiyang 550004, China)

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DOI: 10.19367/j.cnki.1000-2707.2005.01.010

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