贵州医科大学学报

1985, (02) 121-124

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84001抗男性生育的实验研究
EXPERIMENTAL RESEARCHES ON MATE ANTIFERTILITY OF 84001 FRUIT EXTRACT

覃国芳;牟肇龄;
Qin Guofang (Department ot Histology and Embryolgy)

摘要(Abstract):

<正> 对非激素类男性抗生育药物的研究,近年国外取得一些进展,经动物试验证实有抗精子发生的作用。类似研究在我国尚末见报导。为探索和开发既经济、简便又有良效的男性避孕新药,我们选用小白鼠190只进行抗精子发生的研究。共分四组,其中二组雄鼠分别经口给84001浸膏1.5ml/Kg/日和1ml/Kg/日,经过25日后,按1:3与雌鼠进行交配。结果二组母鼠(共56只)100%未孕;二组雄鼠睾丸略小,曲细精管部分萎缩,生精细胞(精母细胞、精子细胞)受到不同程度的损害。但支持细胞和间质细胞未见异常。本研究表明84001浸膏有较明显的抗精子
In order to investigate non-hormonid of male contraception in an economical way as well as for very convenient to use, we made researches on mice. We divided these mice into four groups. Two groups were chronic administration of 84001 fruit extract (1.5ml/kg/day and 1ml/kg/day orally) after twenty-five day, we copulated these groups with female mice in the ratio of one to three. The results are hundred per cent infertility, The tests of two groups become little smaller, the seminiferous tubules atrophy and the spermatogenic cells are impaired in different degree. The sertoli cells and interstitial cell did not show morphological evidence of lesion. Thiss tudy confirms that 84001 fruit extract has the function of antispermatogenesis.

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作者(Author): 覃国芳;牟肇龄;
Qin Guofang (Department ot Histology and Embryolgy)

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