贵州医科大学学报

2006, (01) 24-26+29

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载脂蛋白E基因多态性与散发阿尔茨海默病的关系
Polymorphism in the Apolipoprotein E Gene and Its Association with Sporadic Alzheimer Disease

李光荣;赵明祥;左丽;刘芳;况时祥;
LI Guang-rong~1,ZHAO Ming-xiang~1,ZUO Li~2,LIU Fang~1,KUANG Shi-xiang~3(1.Department of Neurology,The Affiliated Hospital of Guiyang Medical College,Guiyang 550004,China.; 2.Department of Immunology,Guiyang Medical College,Guiyang 550004,China;3.Guiyang College of Traditional Chinese Medicine,Guiyang 550002,China)

摘要(Abstract):

目的:探讨载脂蛋白E(ApoE)基因多态性与散发阿尔茨海默病(sporad ic A lzhe im er d isease,SAD)的关系。方法:通过DNA直接测序的方法检查30例SAD和30例正常老人ApoE基因的3个编码外显子。结果:ApoEε4等位基因频率(23.3%,8.3%)及ε4/4,ε3/4,ε2/4基因型合并后其基因型频率(40%,16.7%)在SAD和对照组之间有显著差异(2χ=5.065,P<0.05;2χ=4.022,P<0.05);SAD组ε2等位基因频率与对照组相比差异不明显。结论:结果提示ApoEε4等位基因为本地区老年人群的危险因素。
Objective: To study the association of polymorphism of ApoE gene with sporadic Alzheimer disease in Guizhou,China.Methods: Three exons of ApoE gene in 30 sporadic Alzheimer disease patients(SAD group) and 30 normol people(control group) were screened with DNA sequencing method.Results: The allelic frequencies of ApoEε4(23.3%,8.3%) and genotype frequencies of ApoEε4/4,ε3/4,and ε2/4 in SAD group(40%,16.7%) were significantly higher than those of control group(χ~2= 5.065,P<0.05;χ~2=4.022,P<0.05).Conclusion: The ApoEε4 alleles might be a genetic risk factor in the occurrence of SAD in Guizhou,China.

关键词(KeyWords): 阿尔茨海默病;多态性,单核苷酸;载脂蛋白E类;聚合酶链反应
Alzheimer disease;polymorphism,single nucleotide;apolipoproteins E;polymerase chain reaction

Abstract:

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基金项目(Foundation): 贵州省省长基金资助项目

作者(Author): 李光荣;赵明祥;左丽;刘芳;况时祥;
LI Guang-rong~1,ZHAO Ming-xiang~1,ZUO Li~2,LIU Fang~1,KUANG Shi-xiang~3(1.Department of Neurology,The Affiliated Hospital of Guiyang Medical College,Guiyang 550004,China.; 2.Department of Immunology,Guiyang Medical College,Guiyang 550004,China;3.Guiyang College of Traditional Chinese Medicine,Guiyang 550002,China)

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DOI: 10.19367/j.cnki.1000-2707.2006.01.008

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