贵州医科大学学报

1999, (03) 229-230+233

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用PCR检测尖锐湿疣患者的6,11型人乳头瘤病毒
Use of Polymerase Chain Reaction For Detection of HPV-6,11 in Condyloma Acuminatum

单可人,何燕,吕筠,钟复光,潘美兰,徐德明,王柄南,周茂梅
Shan Keren,et al Laboratory of Molecular Biology,Guiyang Medical College

摘要(Abstract):

应用聚合酶链反应 (PCR)技术对 198例尖锐湿疣、疑尖锐湿疣患者进行HPV - 6 ,11感染的基因诊断。结果HPV - 6 ,11阳性 142例 ,阳性率 71 7% (142 / 198)。其中尖锐湿疣患者 10 6例 ,HPV - 6 ,11阳性 76例 ,阳性率 71 70 % (76 / 10 6 ) ;疑尖锐湿疣患者 92例 ,HPV - 6 ,11阳性 6 6例 ,阳性率 71 73% (6 6 / 92 )。说明无明显临床症状者 ,经PCR技术检测可得到诊断。
Gene diagnosis with polymerase chain reaction was detected in 198 cases with condyloma acuminatum and doubtful condyloma acuminatum.HPV-6,11 DNA was demonstrated in 142 of 198(71 72%) among which HPV-6,11 DNA was 71 70%(76/106) for condyloma acuminatum and HPV-6,11 DNA was 71 73%(66/92) for doubtful condyloma acuminatum.So PCR technique for selective detecting HPV-6,11 DNA might be helpful to early finding and treatment of condyloma acuminatum and doubtful condyloma acuminatum then to prevent the marlignant changes of cervices.

关键词(KeyWords): 乳头状瘤病毒;尖锐湿疣;聚合酶链反应
papillomaviruses; condylomata acuminata; polymerase chain reaction

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作者(Author): 单可人,何燕,吕筠,钟复光,潘美兰,徐德明,王柄南,周茂梅
Shan Keren,et al Laboratory of Molecular Biology,Guiyang Medical College

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