贵州医科大学学报

1986, (03) 233-236

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甲状腺机能亢进症517例临床分析
CLINICAL ANALYSIS OF 517 CASES OF HYPERTHYROIDISM


Section of Endocrinol Dep of Intern Med

摘要(Abstract):

本文对517例甲状腺机能亢进症进行回顾性分析。结果提示:除甲肿及突眼外,多系统表现至少包括神经兴奋性增高、心悸、心动过速、代谢亢进;~(131)I吸收率及TT_3测定值对甲亢的诊断符合率达98.4%,较TT_4测定值灵敏。TT_3及TT_4同时测定不易漏诊;合理用抗甲状腺药物治疗者痊愈率达72%,欠合理者为44.4%(P<0.001)。以三周抑制试验结果判断病情是否痊愈作为停药指标,其价值尚难定论。
Hyperthyroidism from Sep 1977 to May 1983 are reported in 517 cases. The incidence was 56.8%as compared with total cases of endocrine diseases during the same period. Most of the diagnosis were established within one year. The major clinical features of hyperthyroidism in these patients showed nervousness, palpitation, hypermetabolism besides goiter and exophthalmos. Laboratory examinations showed~(131)I-uptake rate, TT_3 level was more sensitive than TT_4level. The rate of coordination to diagnosis was 98.4%. In some patients~(131)I-uptake of thyroid gland was increased without a forward shift of initial uptake of the ralioiodine and thus is most convincingly demonstratei by the thyroid suppression test.The serum concentrated by thyroid hormone for the hyperthyroidism showed T_3-toxicosis, elevated in TT_4 with normal TT_3 level in serum accounted for 4.8%and 1.5% respectively. The misdiagnosis of hyperthyroidism may be decreased by determination of TT_4 and TT_3 simultaneously. In therapy antithyroid drugs, partial thyroidectomy and radioactive iodine were carried out 76.5%, 0.8%, 22.7%respectively. The cured rate of optimum antithyroid medication group was 72% otherwise it was 44.4% (P<0.001). The result of three weeks thyroid suppression test can predict the final effect of antithyroid drugs therapy clinically. It was the indication for drug withdrawal.

关键词(KeyWords): 甲状腺机能亢进症;甲状突眼症;甲状腺激素;甲状腺桔抗剂
Hyperthyroidism Goiter exophthalmos Thyroid hormone Antithyroid drugs

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Section of Endocrinol Dep of Intern Med

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