贵州医科大学学报

2011, v.36;No.148(01) 19-22

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p57~(kip2) LIMK-1在胃癌组织中的表达及与肿瘤血管和淋巴管的关系
Expression of p57~(kip2) and LIMK-1 in Gastric Cancer and Their Relationships with Tumor Blood Vessel and Lymphatic Vessel

王龙;于燕妮;贺晓燕;
WANG Long,YU Yanni,HE Xiaoyan(Department of Pathology,Guiyang Medical College,Guiyang 550004,Guizhou,China)

摘要(Abstract):

目的:探讨胃癌组织中细胞周期抑制因子p57kip2、LIMK-1与临床病理的关系以及在胃癌浸润转移及肿瘤微淋巴管和微血管形成中的作用。方法:用免疫组织化学方法(EnVision法)检测40例胃癌组织和其对应癌旁组织(距癌灶缘>5 cm)中p57kip2、LIMK-1的表达水平,及检测微淋巴管和微血管密度。结果:p57kip2的表达与胃癌细胞的分化程度有相关性(P<0.05),与临床分期、年龄、肿瘤大小及肿瘤侵犯转移无相关性(P>0.05);p57kip2在胃癌组织中的阳性率为30%,低于癌旁组织(45%)。LIMK-1在胃癌组织中的表达与p57kip2的表达有相关性(P<0.05);淋巴管密度(LVD)和微血管密度(MVD)与p57kip2和LIMK-1表达均呈正相关(P<0.05)。结论:p57kip2和LIMK-1与胃癌细胞的分化程度有关,并参与胃癌组织中的微淋巴管和微血管的形成,进而促进胃癌的发生发展和转移过程。
Objective:To explore the relationship of cell cycle inhibitor,p57kip2,and LIMK-1 to clinical pathology,and to study their roles in gastric cancer invasion,metastasis,and formation of tumor lymphatic vessels and microvessels.Methods: The expression levels of p57kip2 and LIMK-1 in tissues of 40 cases of gastric cancer and adjacent normal tissues(away from the foci edge more than 5 cm) were detected with immunohistochemistry method(Envision method).Lymphatic vessel density(LVD) and microvessel density(MVD) were detected as well.Results: The expression of p57kip2 was associated with gastric cancer cell differentiation(P>0.05),but not associated with clinical stage,patient age,tumor size,tumor invasion and metastasis(P>0.05).The positive rate of p57kip2 in gastric carcinoma was 30% which was lower than that in normal tissue(45%).The expression of LIMK-1 in gastric cancer tissue was correlated with the expression of p57kip2(P<0.05).LVD and MVD in gastric cancer were positively correlated with the expression of p57kip2 and LIMK-1(P<0.05).Conclusions: The expression of LIMK-1 and p57kip2 relates to differentiation of gastric cancer and participate in the formation of lymphatic vessels and microvessels,thus contributing to gastric cancer development and metastasis.

关键词(KeyWords): 胃肿瘤;癌基因蛋白质类;免疫组织化学;癌基因,p57kip2;癌基因,LIMK-1
stomach neoplasms;oncogene proteins;immunohistochemistry;gene,p57kip2;gene,LIMK-1

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基金项目(Foundation): 贵州省优秀科技人才省长基金(编号:黔省专合字[2005]165号)

作者(Author): 王龙;于燕妮;贺晓燕;
WANG Long,YU Yanni,HE Xiaoyan(Department of Pathology,Guiyang Medical College,Guiyang 550004,Guizhou,China)

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DOI: 10.19367/j.cnki.1000-2707.2011.01.007

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