贵州医科大学学报

1990, (04) 252-256

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肺癌病人免疫功能状态观察
Survey of the Immune Status in Patients With Lung Cancer

弋琼;冯家兴;
Yi Qiong and Feng Jiaxing Guizhou Cancer Institute

摘要(Abstract):

同时用多项免疫指标检测了43例肺癌病人,并与12例非肿瘤患者及49名健康人比较。发现肺癌病人免疫功能严重缺陷,尤以NK细胞活性低下为甚。NK细胞活性和T细胞功能较强时,有利于肺癌局限,当二者功能进一步低下时,提示肿瘤已播散。T细胞功能和NK细胞活性变化与癌细胞学类型无关。部分病人血浆有抑制T细胞但不抑制NK细胞活性的物质。NK细胞活性的检测对了解机体的抗肿瘤免疫有重要意义。
A series of examinations for immnne status were done in vitro using the peripheral blood lymphocytes from 42 patients with lung carcinoma, 12 patients with non malignant pulmonary diseases and 49 normal controls.The results showed that in cancer group, NK cell activity measured by the inhibition ~3H-thymidine incorporation assay and T-cell function measured by ~3H-thymidine incoporation were greatly lower than that in the normal control, expecially the former when the lymphocyte is blastogenesis to PHA.The percentage of OKT4~+ cells, the OKT4~+/OKT8~+ measured by avidinbiotin complex system and the percentage of B lymphocytes were depressed significantly.When NK activity and T-cell function were depressed less, the cancer tended to be localized, while when depressed more, we could infer that the cancer has metastasized.In some patients with lung cancer there is a kind of plasma inhibitor which depresses the T-cell function, but does not affect on NK activity.Assays of NK activity and T cell function are useful to understand the anticancer mechanism.

关键词(KeyWords): NK细胞;~3H—TdR;T细胞;血浆抑制物;肺癌
NK cell;T-lymphocyte;~3H-thymidine;Plasma inhibitor;lung cancer

Abstract:

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作者(Author): 弋琼;冯家兴;
Yi Qiong and Feng Jiaxing Guizhou Cancer Institute

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DOI: 10.19367/j.cnki.1000-2707.1990.04.004

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