贵州医科大学学报

2003, (02) 98-100+105

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Y染色体单倍型在贵州苗族人群中的多态性分布
The Polymorphism Distribution of Y - chromosome Haplotypes in A Miao Population of Guizhou

李永念,左丽,文波,黄微,金力
LI Yong-nian, ZUO Li, WEN Bo, HUANG Wei, JIN Li (1. Department of immunology, Guiyang Medical College, Guiyang 550004, China; 2. Chinese National Human Genome Center at Shanghai, Shanghai 201203, China; 3. Institute of Genetic, Fudan University, Shanghai 200433, China)

摘要(Abstract):

目的:调查Y染色体单倍型在贵州省苗族人群中的分布,从父系历史探寻贵州省苗族人的起源和迁移及其与其他民族间的亲缘关系。方法:采用PCR-RFLP法观察了由13个单核苷酸多态位点(SNPs)组成的Y染色体单倍型在贵州省苗族人群中的多态性分布,并将结果与我国其他民族及世界各大洲人群进行比较。结果:贵州省苗族人群中具有我国南方人群特异性的H7、H11和H12单倍型出现,其单倍型分布与我国南方汉族、土家族、彝族、布依族等较为接近,尤以M122(H5+H6)的频率较高。结论:提示贵州省苗族人属于我国南方群体,与南方汉族人及土家族、彝族人有一定的亲缘关系。
Objective: To investigate the polymorphism distribution of Y-chromosome haplotypes in Miao population. Methods: PCR-RFLP was used to detect the frequency of Y - chromosome haplotypes consisted of thirteen single nucleotide polymorphism alleles in Miao people. Results: Nine Y -chromosome haplotypes (H1, H2, H5, H6, H7, H8, H9, H11, H1 2) were found in the samples. The frequency distribution of these haplotypes in Miao people were very similar to that in other southern populations in China, including Han, Tujia, and Yi people. Conclusion: It indicates that there is a closer genetic relationship among southern Han, Tujia, and Yi populations implicating a common ancestry.

关键词(KeyWords): Y染色体;遗传学;,群体;贵州苗族
Y-chromosome; genetics, population; Miao people, Guizhou

Abstract:

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基金项目(Foundation): 国家自然科学基金(39896200)

作者(Author): 李永念,左丽,文波,黄微,金力
LI Yong-nian, ZUO Li, WEN Bo, HUANG Wei, JIN Li (1. Department of immunology, Guiyang Medical College, Guiyang 550004, China; 2. Chinese National Human Genome Center at Shanghai, Shanghai 201203, China; 3. Institute of Genetic, Fudan University, Shanghai 200433, China)

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