贵州医科大学学报

1991, (04) 373-375

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阿司匹林微囊化后溶出度的对比研究
Study on Disolubility of Microencapsulated Aspirin in Comparison with Aspirin Powder

孙容波;邓雁琪;周宝珠;朱在仁;段兴云;谢云淼;
Sun Rongbo. et al Department of Pharmacy

摘要(Abstract):

本文用复凝聚法将阿司匹林微囊化,并作了与阿司匹林胶囊的溶出度对比研究,结果前者比后者的T_(50)缓释128min,Td缓释163min,显示阿司匹林微囊化后缓释效果显著。本研究为将阿司匹林制成缓释长效制剂,拓宽应用范围开辟了一个新的途径。
The disoulbility of the microencapsulated aspirin was campared with that of the aspirin powder. The microencapsulated aspirin was made by method of double coacervation. The slow-released time of both T_(50) and Td in the microencapsulated aspirin were 128 min and 163 min, respectively. It shows that the slow-released effeet of microencapsulated aspirin is very significant. Therefore, the study will open up a new way of making aspirin to longacting and slow-released preparation.

关键词(KeyWords): 阿司匹林;微囊;溶出度
aspirin; microcapsule; disolubility

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作者(Author): 孙容波;邓雁琪;周宝珠;朱在仁;段兴云;谢云淼;
Sun Rongbo. et al Department of Pharmacy

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DOI: 10.19367/j.cnki.1000-2707.1991.04.026

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