贵州医科大学学报

1985, (02) 109-112

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氟骨症患者血清T_4、T_3、TSH含量变化探讨
STUDY ON SERUM T_4, T_3 AND TSH LEVELS IN PATIENTS WITH CHRONIC SKELETAL FLUOROSIS

于燕妮;官志忠;刘家骝;刘尚治;陈友全;
YU Yanni Department of Pathology

摘要(Abstract):

研究了27例氟骨病患者血清T_4、T_3和TSH含量变化,并以20例健康人作对照。结果表明,氟骨症组血清T_4低于对照组,而血清TSH高于对照组,血清T_3无明显改变。在氟骨症患者中未检查出甲状腺肿。本项研究指出,氟通过干扰甲状腺功能使血清T_4含量降低,后者反馈性刺激TSH分泌增加。由于氟可抑制甲状腺对TSH刺激的反应性,故未见到甲状腺肿。
A study on the serum T_4, T_3 and TSH level was performed in 27 patients with Chronic skeletal fluorosis and the data obtained Were comparcd with those of 20 health persons. The results showed that serum T_4 in the patients was lower than in the controls and TSH was higher. While serum T_3 showed no significant difference. There was no goiter found in the patients. These data, indicate that fluorine may reduce serum T_4 by interfering the thyroid function. The increase of TSH secration is the consequence stimulated by a feedback mechanism but no proliferation and enlargement of the thyroid gland were resulted since the reactivity of the thyroid to rise serum TSH stimulation is inhibited by the, fluorine.

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作者(Author): 于燕妮;官志忠;刘家骝;刘尚治;陈友全;
YU Yanni Department of Pathology

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