贵州医科大学学报

1985, (01) 15-18

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139例恶性肿瘤患者外周血自然杀伤细胞活性的研究
NATURAL KILLER CELL MEDIATED CYTOTOXICITY IN PATIENTS WITH MALIGNANCY (Abstract)

庄宗杰;李永琴;高炯源;杨敬修;刘家骝;
Zhuang Zongjie, (Department of Pathophysiology)

摘要(Abstract):

<正> 自从70年代Tukesugi和Rosenberg等发现人体外周血存在不需要抗原致敏、从依赖抗体和补体介导,能直接溶解多种体外培养的人肿瘤细胞株的淋巴细胞以来,自然杀伤细胞(NK细胞)的清除恶变细胞、抗感染和抗异源性组织的非特异免疫功能受到重视,近十年来国外已有不少报导,而国内有关资料报道不多,现将我们有关NK细胞与肿瘤的研究工作报道如下。材料与方法一、分组随机择取经活体组织、细胞学检查证实的各类恶性肿瘤患者139例、其中男性92例,女性47例。另取来自学生、职工、退休工人及献血者等健康个体355例,其中男性193例,女性162例做对照。按年龄分组:幼少年组2~17岁;青
Using K562 target cells labelled with~(125) IUdR, we determined the cytoto- xicity capacity of mononuclear cells from the peripheral blood of 139 patients suffering from cancer and 355 healthy persons. The results indicate clearly that there is a decline in NK cell mediated cytoto- xicity in cancerous patients. The reduced cytotoxicity is assumed one of the factors facilitating tumor growth. This reduction was highly significant in both untreated patients and patients with metastases. We have alsofound that in patients with hepatic carcinoma and patients with advanced disease, the NK activity was the lowest. The level of NK activity varied in different histogenic tumors and was related to the development of the disease. The level of NK activity was risen after surgical treatment and chemotherapy combined with radiotherapy. The results confirm that the tumor growth is relayed to immune serveillance capability.

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作者(Author): 庄宗杰;李永琴;高炯源;杨敬修;刘家骝;
Zhuang Zongjie, (Department of Pathophysiology)

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DOI: 10.19367/j.cnki.1000-2707.1985.01.004

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