贵州医科大学学报

1988, (02) 272-275

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慢性心力衰竭治疗中地戈辛使用剂量的探讨
PROBING INTO A DOSAGE OF DIGITAKIS IN THE TREATMENT OF CONGESTIVE HEART FAILURE

李培;张美祥;姚淙;芦源;
Li Pei,Department of Internal Medicine

摘要(Abstract):

本文报告287例使用地戈辛(D)维持剂量治疗的充血性心力衰竭患者,并结合863次血清地戈辛浓度(SDC)的测定结果进行分析。结果表明:D 0.25mg/d 适用于大部份病人,但高龄患者洋地黄中毒率高达16.6%;D0.125mg/d 适用于50岁以上及伴有心肌炎症的患者,但对年轻患者不适宜;D0.125mg 与0.25mg 隔日交替服用可能也是一种较为理想的治疗方法;D0.5mg/d 是一种不适宜的维持剂量;在维持剂量治疗中仍应严密观察病情,定期测定 SDC。
This aticle reports 287 cases of congestive heart failure which are medicat- ed a maintenance dosage of digoxin and according to the determined result of serum digouin concentration in 863 times,searches a reasonable dosage of di- goxin.This result indicates:1.The method of D 0.25mg/d suits to the majority of the patients but digoxin toxication of the old patients group reaches 16.6%; 2.The method of D 0.125mg/d suits to the patients above fifty and accompan- ing myocarditis,but do not suit to the young group;3.The alternate medica- tion of D 0.25mg/d and D 0.125mg/d may be a ideeal mothod;4.The method of D 0.5mg/d is a unsuitable dosage;5.Within the treatment perlod of using a maintenance dosage of digoxin,we must closely the state of an illness and regularly determine seturn digoxin concentration.

关键词(KeyWords): 地戈辛;;血清诊断;;充血性心力衰竭
Digoxin;;Serodiagnosis;;Heart failure;;congestive

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作者(Author): 李培;张美祥;姚淙;芦源;
Li Pei,Department of Internal Medicine

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