贵州医科大学学报

2010, v.35;No.146(05) 472-475

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妇科肿瘤化疗患者骨髓抑制危险因素分析
Retrospective Analysis on Risk Factors of Myelosuppression in Patients with Gynecological Neoplasms and Received Chemotherapy

矫洁;周遵伦;黄林;
JIAO Jie,ZHOU Zunlun,HUANG Lin (Department of Gynecology,the Affiliated Hospital of Guiyang Medical College,Guiyang 550004,Guizhou,China)

摘要(Abstract):

目的:探讨妇科肿瘤患者化疗后骨髓抑制的预防。方法:对272例妇科肿瘤患者化疗前的临床症状、血象及KPS评分等临床资料进行回顾性分析。结果:骨髓抑制发生的相关危险因素有化疗前KPS评分≤60分、多次化疗及化疗前白细胞低于正常;骨髓抑制临床症状多样性,无特异性;在骨髓抑制好发期监测血象及伴随症状,可以预防性治疗,减少骨髓抑制及伴随症的发生。结论:妇科肿瘤化疗患者的骨髓抑制是多种复杂因素共同作用的结果,重视患者化疗前KPS评分、监测骨髓抑制好发期的血象及伴发症状,有助于预防化疗后的骨髓抑制。
Objective: To study the method of protecting gynecologic tumor patients against myelosuppression after chemotherapy.Methods: Clinical data including risk factors of myelosuppressio and clinical manifestations of 272 patients with gynecological tumor received chemotherapy were analyzed retrospectively.Results: Risk factors of myelosuppression were KPS scores ≤ 60,multiple chemotherapy,and leukopenia before chemotherapy.The clinical symptoms of myelosuppression were diversity,and non-specific.In the period when myelosuppression was easy to occur,strengthening monitoring on blood and complications,and early detection and treatment,can reduce myelosuppression and incidence of complications,and improve curative results.Conclusions: There are differences among people in terms of risk factors to myelosuppression occurrence.Independent factor can forecast myelosuppression occurrence more accurately,but we can not identify individual factor at present.

关键词(KeyWords): 卵巢肿瘤;子宫肿瘤;药物疗法,联合;骨髓
ovarian neoplasms;uterine neoplasms;drug therapy,combination;bone marrow

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作者(Author): 矫洁;周遵伦;黄林;
JIAO Jie,ZHOU Zunlun,HUANG Lin (Department of Gynecology,the Affiliated Hospital of Guiyang Medical College,Guiyang 550004,Guizhou,China)

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DOI: 10.19367/j.cnki.1000-2707.2010.05.012

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