贵州医科大学学报

1987, (04) 322-324+405

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恶性骨肿瘤治疗的研究 (一)骨灭活再植的实验研究
STUDY ON MALIGNANT BONE TUMOR THERAPY(1)EXPERIMENTAL STUDY OF DEVITALIZED BONE REPLANTATION

陈雄德;付家智;杨启友;庄铅秀;曾宪筠;邓传静;
Chen Xiongde Dep of Orthopedics

摘要(Abstract):

通过切取30只家兔的双侧桡骨远端用不同药物灭活后再植的实验研研,发现:0.25%氨甲喋呤、0.1%环磷酰胺和0.1%新洁尔灭引起骨细胞损害最明显;95%酒精对正常骨细胞伤害较轻,是目前较好的骨灭活药物。
Thirty healthy adult rabbits were evenly devided into 6 groups at random. Each animal,1.5cm of the distal end of both radii were excised and immersed in the following solutions 30 minutes to devitalize.Rabbit No.1 in each group immersed in 0.25% methotrexate,while No.2 in 0.1% cyclophosphamide,No.3 in 0.1%brom-geramine,No.4 in 95% alcohol,and No.5 in normal saline for control.4 drops of 2% methylene blue were added to each of the above solutions as tracer.After devitation,except group 1,the others were replanted in situs.According to the group No.2-6,the animals were killed at 3rd,7,14,21,and 30 day after replantation.All the replanted and un- replanted radii were examined histologically to compare the degree of normal bone cells damaged by the chemicals.We found 95% alc.did less damage,and beleived it is a better chemical in devitalized bone replantation at present.

关键词(KeyWords): 成骨肉瘤;自体移植;乙醇;氨甲喋呤;环磷酰胺
Sarcoma,osteogenic Transplantation,autologous Alcohl,ethyl Methotrexate Cyclophosphamide

Abstract:

Keywords:

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作者(Author): 陈雄德;付家智;杨启友;庄铅秀;曾宪筠;邓传静;
Chen Xiongde Dep of Orthopedics

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DOI: 10.19367/j.cnki.1000-2707.1987.04.006

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