贵州医科大学学报

1985, (02) 125-129

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骨髓增生异常综合征Ⅰ——38例临床分析
MYELODYSPLASTIC SYNDROMEA CLINICAL ANALYSIS OF 38 CASES

杨爱云;李继勋;
Yang Aiyun (Department of Internal Medicine)

摘要(Abstract):

<正> 1976年FAB协作组在讨论急性白血病(急白)分类建议时,提出了易与急白混淆的骨髓增生异常综合征(Mgelodysplas-tie Syndromes简称MDS)并将其分为“有过多原始细胞的难治性贫血”,与”慢性粒-单核细胞白血病”两型。前者包括“白血病前期”、“冒烟型白血病”,“非典型白血病”等等。以后发现前述两型不能概括不同类型的MDS,当时也未确定MDS具有预后意义,或发展为急自趋势的特征,因而于1982年提出MDS新的诊断标准,将其分为5型。本文根据此新标准,将我院血液室1974-1984年所见38例的资料分析报告如下:
Clinical manifestations of 38 cases with myelodysplastic syndrome (MDS) were analyses according to the proposals of the FAB co-operative group 1982. According to the new criteria, refractory anemia (RA) was found in 6patien- ts, refratory anemia with ringed sideroblastt(SRA)in 3, refractory anemia with exscess of blasts (RAEB) in 14, chronic myelomonocytic leukemia (CMML) in 14 and RAEB in transformation (T-RAEB) in 5. Among these 38 cases with MDS, it was 1.2 times as common in males as in females and the age over 41 years was in 52.6%. There were some diffe- rences from each group in the clinical manifestations. In the Patients with CMML and T-RAEB, the onset may be abrupt and the duration from the onset to addmission may be below6months. Anemia, hemorrhage, fever and hepatos- plenomegaly were commonly found, However in the patients with RA and SRA. the course prior to admission may be longer, anemia and hemorrhage were the essential fectures and hepatomegaly was presented only in a few cases. 16 cases were followed up, 8of them developed acute leukemia (5with RAEB, 2with T-RAEB and 1 with CMML), 4patiets died of infection or he- morrhage (2. with RAEB and 2with T-RAEB), 1 patient was associated with primary carcinoma of the liver ( 1 with RAEB) and 3 patients survived for 2years, 10 years and 11 years respectively (2with RA and 1 with SRA).

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作者(Author): 杨爱云;李继勋;
Yang Aiyun (Department of Internal Medicine)

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