贵州医科大学学报

1996, (03)

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甲型和乙型病毒性肝炎患者血清可溶性白细胞介素-2受体水平变化
The Changes of Soluble Interleukin-2 Receptors Levels in the Serum of Hepatitis A and B Patients

关磊晶,沈燕,肖庆生,熊金凤
Guan Leijing;et al(Guiyang 5th People's Hospital)

摘要(Abstract):

检测了56例甲型和乙型病素性肝炎患者血清可溶性白细胞介素-2受体(sI1-2R)水平。结果与对照组相比除乙肝病毒携带者外,其余患者血清sI1-2R水平均增高,sI1-2R水平与谷丙转氨酶、黄疸指数呈正相关。乙肝患者病毒复制活跃者sI1-2R水平升高亦较明显。本文表明,血清sI1-2R水平可作为临床病情监测和预后判断的一项指标。
The levels of soluble interleukin-2 receptors were detected in 356 cases of hepatitis A and B patients by using ELISA method. The result showed that sIL-2R levels in the serum of these patients were all at 36 8.9~1450.1U/ml,which were marked elevated than that of the control group(24.1U/ml)(P<0.05, P<0.01).The sIL-2R levels showed positive corelation with liver function deterioration and the degree of deplicating activity of hepatitis B virus. The levels in chronic type and severe type of hepatitis A and B were relatively higher while that in chronic persistent hepatitis and posthepatitic cirrliosis of liver were relatively lower.There were no marked difference in hepatitis B virus carriers and control group.Therefore the changes in serum sIL-2R level may reflect the pathological changes of the liver and the sererity of inflammation and it may be served as an indicator to monitor the diseased condition and prognostic judgment.

关键词(KeyWords): 可溶性白细胞介素-2受体,甲型肝炎,乙型肝炎
soluble interleukin-2 receptor;hepatitis A; hepatilis B

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作者(Author): 关磊晶,沈燕,肖庆生,熊金凤
Guan Leijing;et al(Guiyang 5th People's Hospital)

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