贵州医科大学学报

1999, (03) 216-220

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p53在NSCLC中不同表达定位及预后价值
Prognosis Value of p53 Overexpression Pattern in NSCLC

杨勤,尔西丁
Yang Qing, et al Department of Pathophysiology, Guiyang Medical College

摘要(Abstract):

用DO 7单克隆抗体 ,以免疫组化的方法观察了 4 2例手术切除的非小细胞肺癌 (NSCLC)病人肿瘤组织 p53表达 ,着重研究不同的亚细胞定位 (核表达阳性或胞浆表达阳性 ) ,在NSCLC的病程发展及预后中的意义。 4 2例NSCLC中 ,有 2 0例出现 p53表达阳性 ,其中 8例为核表达阳性 ,12例为胞浆表达阳性 ,这两种不同的表达定位与病人的病理分期有关。p 53核表达阳性多见于Ⅲ~Ⅳ期病人 ,而胞浆表达阳性多见于Ⅰ~Ⅱ期病人 (P =0 0 32 ) ,而且在术后随访的 30个月中 ,4例死亡的病例中 3例为 p53核表达阳性。研究结果提示 ,NSCLC中 p53胞浆表达阳性代表了早期的肿瘤亚群或低恶性程度的变异 ,而核表达阳性与肿瘤的高恶性度及进展有关 ,p53表达的这种不同亚细胞定位代表不同程度的p53突变 ,核表达阳性可认为是NSCLC不良预后的指征。
p53 gene mutations are the most freqnant genetic alterations detected in human lung cancer. In non-small cell lung cancer, however, the clinicpathological studies of p53 have yield conflicting results. In the current study, p53 was studied by immunohischemistry in 42 NSCLC patient samples after tumor resection. p53 expression and localization (nuclear or cytoplasmic) were evaluated with monoclonal DO-7. Twenty samples of forty-two samples (47.6%) overexpressed p53 protein with 8 cases in nuclear (N) pattern and 12 in cytoplasmic (C) one. The two patterns are significantly related to disease stage (Ⅰ-Ⅱ/C vs. Ⅲ-Ⅳ/N, P=0.032). Moreover, in 30 months follow-up, 4 patients died of the disease. 3 of whom presenting the (N) pattern of p53 overexpression. Our data suggest that p53 cytoplasmic localization represent an early tumor cell population with low grade of neoplastic development, while the nuclear one, possibly carrying a mutated p53 , associated with tumor progression. The nuclear localization of the p53 gene product may be confirmed as a factor of prognostic relevance.

关键词(KeyWords): 癌;非小细胞肺;蛋白质p53;预后
carcinoma, non-small cell lung; protein p53 ; prognosis

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作者(Author): 杨勤,尔西丁
Yang Qing, et al Department of Pathophysiology, Guiyang Medical College

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