贵州医科大学学报

1991, (03) 195-197

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贵州水城氟铝联合中毒病区患者六项生化指标测定分析
Analyses of Six Biochemical Values in Patients with F-AL Combined Toxieosis in Shuieheng Area

黄铁生;韓昉;车筑平;吴发义;方士杰;程学方;赵方贵;
Huang Tiesheng,et al Department of Clinical Biochemistry

摘要(Abstract):

本文报告了84例氟铝联合中毒患者及47例健康人血清的乳酸脱氢酶(LDH)、肌酸磷酸激酶(CPK)、硷性磷酸酶(ALP)、钙(Ca~(2+))、磷(P~(2-))及镁(Mg~2)六项生化指标的分析。其中患者的LDH、CPK、Ca~2、P~(2-)均上升(P<0.01)、ALP下降(P<0.01),而Mg~2与健康人(对照组)对比无差异(P>0.5)。表明高铝环境中氟中毒的生化表现较单纯氟中毒复杂,支持了氟、铝联合作用或合并中毒的设想。
The serum levels of lactate dehydrogenase (LDH), ereatine phosphokinase, alkaline phosphatase (ALP), Ca, P and Mg were measured in 84 patients with fluorosis and 47 healthy volunteers in Shuieheng, an endemic fluorosis area with high aluminum content, of Guizhou provineeo The levels of LDH, CPK, Ca and P of the patients were higher than those of the controls (P<0.01,LDH=142±4u/L, CPK=178±7u/L, Ca~2=2.90±0.03 mmol/L,P~(2-)=1.70±0.01mmol/L, mean±SD), while the level of the patients'ALP was lower (P<0.01, 40±4 SDu/L). There was not any significant change in the patients'Mg~2 level (P>0.5,0.76±0.03mmol/L). The results reflected that the biochemical manifestations of endemie fluorosis in high aluminum-containing environment were more complicated than those of simple fluorosis, thereby suggesting the possibility of F-Al combined toxicosis.

关键词(KeyWords): 氟化物中毒;铝;乳酸脱氢酶;肌酸磷酸激酶;硷性磷酸酶;钙;磷;镁
fluoride poisoning; aluminum; lactate dehydrogenase; creatine phosphokinase; alkaline phosphatase; calcium; phosphorus; magnesium

Abstract:

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作者(Author): 黄铁生;韓昉;车筑平;吴发义;方士杰;程学方;赵方贵;
Huang Tiesheng,et al Department of Clinical Biochemistry

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DOI: 10.19367/j.cnki.1000-2707.1991.03.003

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