王良宏;熊晓丽;孙贵光;田智;
WANG Lianghong,XIONG Xiaoli,SUN Guiguang,TIAN Zhi(1.Department of Clinical Laboratory,Guiyang Medical College,Guiyang 550004,China;2.Department of Equipment,Guiyang Medical College,Guiyang 550004,China)

• 1:贵阳医学院检验系
• 2:贵阳医学院设备处
• 3:贵阳医学院检验系
• 4:贵阳医学院检验系 贵州贵阳550004

摘要(Abstract)：

目的:探讨β-羟丁酸测定在糖尿病酮症或酮症酸中毒诊断中的意义。方法:采用酶速率法测定并比较非酮症糖尿病组(NDK)、糖尿病酮症组(DK)和糖尿病酮症酸中毒组(DKA)血β-羟丁酸的浓度变化。结果:β-羟丁酸在非酮症糖尿病组、糖尿病酮症组及糖尿病酮症酸中毒组随血酮体的增加而上升,且差异显著(P<0.05)。结论:血清β-羟丁酸测定对糖尿病酮症及酮症酸中毒的诊断具有重要的意义。
Objective: To explore the significance of the test of serum β-hydroxybutyric acid(HDA) in diagnosis of diabetic ketoacidosis(DKA).Methods: The serum HDA contents of patients in non-ketosis diabetes(NKD) group,ketosis diabetes(KD) group,and diabetic ketoacidosis(DKA) group were tested with enzyme velocity method and the data were compared.Results: The content of serum HDA of patients in group DKA was significantly higher(P<0.01) than those of diabetes patients in other two groups,and the serum HDA contents increased along with the increase of serum acetone contents.Conclusions: The content of serum HDA shows certain sensitivity and specialties.It can be used as a kind of indexes for clinical diagnosis of DKA.

关键词(KeyWords)： 糖尿病;糖尿病酮症酸中毒;β-羟丁酸
diabetes mellitus;diabetic ketoacidosis;β-hydroxybutyric acid

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 王良宏;熊晓丽;孙贵光;田智;
WANG Lianghong,XIONG Xiaoli,SUN Guiguang,TIAN Zhi(1.Department of Clinical Laboratory,Guiyang Medical College,Guiyang 550004,China;2.Department of Equipment,Guiyang Medical College,Guiyang 550004,China)

Email:

DOI: 10.19367/j.cnki.1000-2707.2007.05.016

参考文献(References)：

• [1]叶任高.内科学[M].5版.北京:人民卫生出版社,2000:820-825.
• [2]康格非.临床生物化学和生物化学检验[M].2版.北京:人民卫生出版社,1997:37-38.
• [3]宋文琪,张美和.血清β-羟丁酸测定在小儿Ⅰ型糖尿病并发酮症及酮症酸中毒中的应用[J].上海医学检验杂志,2002(17):219-220.
• [4]祝其锋.生物化学[M].广州:广东科技出版社,1997:120-125.
• [5]帅虎,梅敏,李海珠,等.血β-羟丁酸的测定在糖尿病及糖尿病酮症酸中毒中的应用[J].齐鲁医学检验,2005(2):9-10.
• [6]衡湘军,易斌,刘阳.血清β-羟丁酸测定方法及其在糖尿病酮症酸中毒中的意义[J].武警医学,2005(11):819-820.

文章评论(Comment)：