贵州医科大学学报

2007, No.128(05) 499-500

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血清β-羟丁酸检测在糖尿病酮症酸中毒诊断中的应用
The Application of Serum β-hydroxybutyric Acid in Diagnosis of Diabetic Ketoacidosis

王良宏;熊晓丽;孙贵光;田智;
WANG Lianghong,XIONG Xiaoli,SUN Guiguang,TIAN Zhi(1.Department of Clinical Laboratory,Guiyang Medical College,Guiyang 550004,China;2.Department of Equipment,Guiyang Medical College,Guiyang 550004,China)

摘要(Abstract):

目的:探讨β-羟丁酸测定在糖尿病酮症或酮症酸中毒诊断中的意义。方法:采用酶速率法测定并比较非酮症糖尿病组(NDK)、糖尿病酮症组(DK)和糖尿病酮症酸中毒组(DKA)血β-羟丁酸的浓度变化。结果:β-羟丁酸在非酮症糖尿病组、糖尿病酮症组及糖尿病酮症酸中毒组随血酮体的增加而上升,且差异显著(P<0.05)。结论:血清β-羟丁酸测定对糖尿病酮症及酮症酸中毒的诊断具有重要的意义。
Objective: To explore the significance of the test of serum β-hydroxybutyric acid(HDA) in diagnosis of diabetic ketoacidosis(DKA).Methods: The serum HDA contents of patients in non-ketosis diabetes(NKD) group,ketosis diabetes(KD) group,and diabetic ketoacidosis(DKA) group were tested with enzyme velocity method and the data were compared.Results: The content of serum HDA of patients in group DKA was significantly higher(P<0.01) than those of diabetes patients in other two groups,and the serum HDA contents increased along with the increase of serum acetone contents.Conclusions: The content of serum HDA shows certain sensitivity and specialties.It can be used as a kind of indexes for clinical diagnosis of DKA.

关键词(KeyWords): 糖尿病;糖尿病酮症酸中毒;β-羟丁酸
diabetes mellitus;diabetic ketoacidosis;β-hydroxybutyric acid

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作者(Author): 王良宏;熊晓丽;孙贵光;田智;
WANG Lianghong,XIONG Xiaoli,SUN Guiguang,TIAN Zhi(1.Department of Clinical Laboratory,Guiyang Medical College,Guiyang 550004,China;2.Department of Equipment,Guiyang Medical College,Guiyang 550004,China)

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DOI: 10.19367/j.cnki.1000-2707.2007.05.016

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