贵州医科大学学报

2018, v.43;No.214(07) 812-815

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丁苯酞氯化钠注射液联合依达拉奉对急性脑梗死患者神经功能及日常生活能力的影响
Effects of Butyphthalide Sodium Chloride Injection Combined with Edaravone on Neurological Function and Activities of Daily Living in Patients with Acute Cerebral Infarction

李俊;庞洪波;胡勇;徐文锐;季学磊;许弘飞;
LI Jun;PANG Hongbo;HU Yong;XU Wenrui;JI Xuelei;XU Hongfei;Department of Neurology,Wuhu Second People's Hospital;Suzhou University;

摘要(Abstract):

目的:探讨丁苯酞氯化钠注射液联合依达拉奉对急性脑梗死患者神经功能及日常生活能力的影响。方法:90例急性脑梗死患者,均分为依达拉奉组、丁苯肽组及两种药物联合组,3组患者在常规急性脑梗死治疗的基础上,分别给与相应药物治疗;于治疗前及治疗2周时,分别采用美国国立卫生研究院制定的卒中量表评分(NIHSS)和日常生活能力量表(Barthel指数)评价患者的神经功能及日常生活能力,比较3组患者治疗2周时的治疗效果及不良反应。结果:治疗前,3组患者NIHSS评分及Barthel指数比较,差异无统计学意义(P>0.05);治疗2周时,3组患者Barthel指数均显著高于治疗前、NIHSS评分显著低于治疗前(P<0.05);联合组患者治疗2周时的Barthel指数显著高于依达拉奉组及丁苯肽组,NIHSS评分显著低于依达拉奉组及丁苯肽组(P<0.05),依达拉奉组、丁苯肽组治疗2周时Barthel指数级及NIHSS评分比较,差异无统计学意义(P>0.05);治疗2周时,联合组患者总有效率显著高于依达拉奉组和丁苯肽组(P<0.05),依达拉奉组与丁苯肽组总有效率比较,差异无统计学意义(P>0.05)。结论:丁苯酞氯化钠注射液联合依达拉奉治疗急性脑梗死治疗效果优于单一丁苯酞氯化钠注射液或依达拉奉用药。
Objective: To explore the effects of butyphthalide sodium chloride injection combined with Edaravone on neurological function and activities of daily living in patients with acute cerebral infarction. Methods: 90 patients with acute cerebral infarction were divided into three groups: Edaravone group,butadiene-butadiene group and two drugs combination group. Three groups of patients were treated with corresponding drugs on the basis of routine treatment of acute cerebral infarction. Before treatment and 2 weeks after treatment,neurologic function and ADL were evaluated by stroke scale( NIHSS) and ADL scale( Barthel index) developed by the National Institutes of Health in the United States. The efficacy and adverse reactions of three groups were compared at 2 weeks of treatment.Results: There was no significant difference in NIHSS score and Barthel index between the three groups before treatment( P > 0. 05). At the 2 weeks of treatment,the Barthel index of the 3 groups was significantly higher than that before treatment,and the NIHSS score was significantly lower than that before treatment( P < 0. 05). The Barthel index in the combined group was significantly higher than that in the Edaravone group and the butadiene-butadiene group at 2 weeks,and NIHSS score was significantly lower than that in Edaravone group and butadiene-butadiene group( P < 0. 05). There was no significant difference in Barthel index and NIHSS score between Edaravone group and butadipine group at 2 weeks( P > 0. 05). At 2 weeks after treatment,the total effective rate in the combined group was significantly higher than that in the Edaravone group and the butadiene-butadiene group( P < 0. 05).There was no significant difference in the total effective rate between Edaravone group and butadiene peptide group( P > 0. 05). Conclusion: The efficacy of butyphthalide sodium chloride injection combined with Edaravone in the treatment of acute cerebral infarction is better than that of butyphthalide sodium chloride injection or Edaravone injection.

关键词(KeyWords): 脑梗塞,急性;神经功能缺损评分;日常生活能力量表;依达拉奉;丁苯肽
cerebral infarction,acute;neurological impairment score;activity of daily living scale;edaravone;phenylbutoxide

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金(81302617);; 安徽省年度重点科研计划项目(1301043052)

作者(Author): 李俊;庞洪波;胡勇;徐文锐;季学磊;许弘飞;
LI Jun;PANG Hongbo;HU Yong;XU Wenrui;JI Xuelei;XU Hongfei;Department of Neurology,Wuhu Second People's Hospital;Suzhou University;

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DOI: 10.19367/j.cnki.1000-2707.2018.07.015

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